Journal Article

DZNE-2025-01299

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dermal Alpha‐Synuclein Aggregation in Seed Amplification Assays for Parkinson's Disease Subtype Differentiation

Vieregge, M. ; Kuzkina, A. ; Janzen, A. ; Oertel, W. H. ; Sommerauer, M.DZNE* ; Volkmann, J. ; Doppler, K.

2025
Wiley-Blackwell Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1111/ene.70453

Abstract: Skin biopsies and seed amplification assays (SAA) provide a sensitive and potentially quantitative method to detect alpha-synuclein (a-syn) aggregation in peripheral nerve fibers in Parkinson's disease (PD). Relating to the previously published hypothesis that PD may either originate in the peripheral (body-first) or central (brain-first) nervous system, we investigated whether patients with clinical features that have been reported to be associated with a suspected body-first subtype of PD exhibit higher levels of a-syn aggregation in dermal nerve fibers compared to those without these features. Patients with isolated REM sleep behavior disorder (iRBD) representing a suspected premotor stage of body-first PD were studied in comparison to the PD cohort.Patients were categorized on the basis of clinical features, and SAA parameters such as lag time, number of positive curves, and titers were analyzed and correlated with clinical features.Although patients with clinical features of suspected body-first PD showed slightly higher titers, significant differences were mainly observed between iRBD patients and PD patients.Our data suggest that widespread α-syn aggregation in advanced PD limits the use of SAA in skin biopsies for subtype differentiation.

Keyword(s): Humans (MeSH) ; Parkinson Disease: metabolism (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Parkinson Disease: classification (MeSH) ; Parkinson Disease: pathology (MeSH) ; Parkinson Disease: complications (MeSH) ; alpha-Synuclein: metabolism (MeSH) ; Male (MeSH) ; Female (MeSH) ; Aged (MeSH) ; Skin: metabolism (MeSH) ; Skin: pathology (MeSH) ; Skin: innervation (MeSH) ; Middle Aged (MeSH) ; REM Sleep Behavior Disorder: metabolism (MeSH) ; Parkinson's disease ; REM sleep behavior disorder ; alpha‐synuclein ; seeding amplification assay ; skin biopsy ; alpha-Synuclein

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Contributing Institute(s):

1. Vascular Neurology (AG Petzold)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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