TY  - JOUR
AU  - Lohner, Valerie
AU  - Perna, Laura
AU  - Schöttker, Ben
AU  - Perneczky, Robert
AU  - Kliegel, Matthias
AU  - Brenner, Hermann
AU  - Mons, Ute
TI  - Prospective associations of blood-based biomarkers of neurodegenerative diseases with cognitive performance in a cohort of patients with chronic coronary syndrome.
JO  - Journal of Alzheimer's disease
VL  - 108
IS  - 4
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2025-01361
SP  - 1507 - 1513
PY  - 2025
AB  - In a cohort of persons with chronic coronary syndrome, we investigated associations of blood-based biomarkers of neurodegenerative diseases with cognitive scores and mild cognitive impairment (MCI) after ten years. Biomarker levels were measured in baseline samples of serum (glial fibrillary acid protein, neurofilament light chain (NfL), phosphorylated tau181; n = 363) or plasma (amyloid-β42/40-ratio, total-tau; n = 232). Cognitive scores and MCI were measured at ten-year follow-up using the Cognitive Telephone Screening Instrument. At follow-up, 14.7
KW  - Humans
KW  - Male
KW  - Female
KW  - Biomarkers: blood
KW  - Aged
KW  - Cognitive Dysfunction: blood
KW  - Cognitive Dysfunction: psychology
KW  - Neurofilament Proteins: blood
KW  - Middle Aged
KW  - Amyloid beta-Peptides: blood
KW  - tau Proteins: blood
KW  - Prospective Studies
KW  - Neurodegenerative Diseases: blood
KW  - Neurodegenerative Diseases: complications
KW  - Cohort Studies
KW  - Peptide Fragments: blood
KW  - Glial Fibrillary Acidic Protein: blood
KW  - Neuropsychological Tests
KW  - Cognition: physiology
KW  - Alzheimer's disease (Other)
KW  - amyloid-beta ratio (Other)
KW  - biomarkers of neurodegenerative diseases (Other)
KW  - chronic coronary syndrome (Other)
KW  - cognition (Other)
KW  - epidemiology (Other)
KW  - mild cognitive impairment (Other)
KW  - neurofilament light chain (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - Peptide Fragments (NLM Chemicals)
KW  - neurofilament protein L (NLM Chemicals)
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41252287
DO  - DOI:10.1177/13872877251389147
UR  - https://pub.dzne.de/record/282603
ER  -