Journal Article

DZNE-2025-01361

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prospective associations of blood-based biomarkers of neurodegenerative diseases with cognitive performance in a cohort of patients with chronic coronary syndrome.

Lohner, V. ; Perna, L. ; Schöttker, B. ; Perneczky, R.DZNE* ; Kliegel, M. ; Brenner, H. ; Mons, U.

2025
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.1177/13872877251389147

Abstract: In a cohort of persons with chronic coronary syndrome, we investigated associations of blood-based biomarkers of neurodegenerative diseases with cognitive scores and mild cognitive impairment (MCI) after ten years. Biomarker levels were measured in baseline samples of serum (glial fibrillary acid protein, neurofilament light chain (NfL), phosphorylated tau181; n = 363) or plasma (amyloid-β42/40-ratio, total-tau; n = 232). Cognitive scores and MCI were measured at ten-year follow-up using the Cognitive Telephone Screening Instrument. At follow-up, 14.7% had MCI. The amyloid-β42/40-ratio was predictive of cognitive scores, while NfL was associated with increased risk of MCI, suggesting that these biomarkers might be utilized for risk stratification.

Keyword(s): Humans (MeSH) ; Male (MeSH) ; Female (MeSH) ; Biomarkers: blood (MeSH) ; Aged (MeSH) ; Cognitive Dysfunction: blood (MeSH) ; Cognitive Dysfunction: psychology (MeSH) ; Neurofilament Proteins: blood (MeSH) ; Middle Aged (MeSH) ; Amyloid beta-Peptides: blood (MeSH) ; tau Proteins: blood (MeSH) ; Prospective Studies (MeSH) ; Neurodegenerative Diseases: blood (MeSH) ; Neurodegenerative Diseases: complications (MeSH) ; Cohort Studies (MeSH) ; Peptide Fragments: blood (MeSH) ; Glial Fibrillary Acidic Protein: blood (MeSH) ; Neuropsychological Tests (MeSH) ; Cognition: physiology (MeSH) ; Alzheimer's disease ; amyloid-beta ratio ; biomarkers of neurodegenerative diseases ; chronic coronary syndrome ; cognition ; epidemiology ; mild cognitive impairment ; neurofilament light chain ; Biomarkers ; Neurofilament Proteins ; Amyloid beta-Peptides ; tau Proteins ; Peptide Fragments ; neurofilament protein L ; Glial Fibrillary Acidic Protein

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Contributing Institute(s):

1. Vascular Cognitive Impairment & Post-Stroke Dementia (AG Dichgans)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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