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@ARTICLE{Lohner:282603,
      author       = {Lohner, Valerie and Perna, Laura and Schöttker, Ben and
                      Perneczky, Robert and Kliegel, Matthias and Brenner, Hermann
                      and Mons, Ute},
      title        = {{P}rospective associations of blood-based biomarkers of
                      neurodegenerative diseases with cognitive performance in a
                      cohort of patients with chronic coronary syndrome.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {108},
      number       = {4},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2025-01361},
      pages        = {1507 - 1513},
      year         = {2025},
      abstract     = {In a cohort of persons with chronic coronary syndrome, we
                      investigated associations of blood-based biomarkers of
                      neurodegenerative diseases with cognitive scores and mild
                      cognitive impairment (MCI) after ten years. Biomarker levels
                      were measured in baseline samples of serum (glial fibrillary
                      acid protein, neurofilament light chain (NfL),
                      phosphorylated tau181; n = 363) or plasma
                      (amyloid-β42/40-ratio, total-tau; n = 232). Cognitive
                      scores and MCI were measured at ten-year follow-up using the
                      Cognitive Telephone Screening Instrument. At follow-up,
                      $14.7\%$ had MCI. The amyloid-β42/40-ratio was predictive
                      of cognitive scores, while NfL was associated with increased
                      risk of MCI, suggesting that these biomarkers might be
                      utilized for risk stratification.},
      keywords     = {Humans / Male / Female / Biomarkers: blood / Aged /
                      Cognitive Dysfunction: blood / Cognitive Dysfunction:
                      psychology / Neurofilament Proteins: blood / Middle Aged /
                      Amyloid beta-Peptides: blood / tau Proteins: blood /
                      Prospective Studies / Neurodegenerative Diseases: blood /
                      Neurodegenerative Diseases: complications / Cohort Studies /
                      Peptide Fragments: blood / Glial Fibrillary Acidic Protein:
                      blood / Neuropsychological Tests / Cognition: physiology /
                      Alzheimer's disease (Other) / amyloid-beta ratio (Other) /
                      biomarkers of neurodegenerative diseases (Other) / chronic
                      coronary syndrome (Other) / cognition (Other) / epidemiology
                      (Other) / mild cognitive impairment (Other) / neurofilament
                      light chain (Other) / Biomarkers (NLM Chemicals) /
                      Neurofilament Proteins (NLM Chemicals) / Amyloid
                      beta-Peptides (NLM Chemicals) / tau Proteins (NLM Chemicals)
                      / Peptide Fragments (NLM Chemicals) / neurofilament protein
                      L (NLM Chemicals) / Glial Fibrillary Acidic Protein (NLM
                      Chemicals)},
      cin          = {AG Dichgans},
      ddc          = {610},
      cid          = {I:(DE-2719)5000022},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41252287},
      doi          = {10.1177/13872877251389147},
      url          = {https://pub.dzne.de/record/282603},
}