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000283027 037__ $$aDZNE-2025-01439
000283027 041__ $$aEnglish
000283027 1001_ $$aPostina, Rolf$$b0
000283027 245__ $$aADAM10, myelin-associated metalloendopeptidase
000283027 260__ $$bElsevier$$c2025
000283027 29510 $$aHandbook of Proteolytic Enzymes / Postina, Rolf ; : Elsevier, 2025, ; ISBN: 9780443288494 ; doi:10.1016/B978-0-443-28849-4.00185-5
000283027 300__ $$a1185 - 1194
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000283027 520__ $$aThe subject of this chapter is ADAM10, myelin-associated metalloendopeptidase. ADAM10 is a zinc-dependent metallo-endopeptidase with a C-terminal distintegrin domain. It is a homolog of adamalysin. As an α-secretase, it is protective against Alzheimer’s disease, cleaving the Aβ protein so that the damaging β-secretase cleavage is reduced. ADAM10 is a sheddase and releases soluble ectodomains from a variety of membrane-bound proteins including cadherins. Unusually, in the precursor, the C-terminus blocks the active site. Interactions with different tetraspanins affect activation and substrate specificity.
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000283027 7001_ $$0P:(DE-HGF)0$$aFahrenholz, Falk$$b1$$eLast author
000283027 773__ $$a10.1016/B978-0-443-28849-4.00185-5
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