Contribution to a book

DZNE-2025-01439

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png ADAM10, myelin-associated metalloendopeptidase

Postina, R. ; Fahrenholz, F. (Last author)DZNE*

2025
Elsevier

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Please use a persistent id in citations: doi:10.1016/B978-0-443-28849-4.00185-5

Abstract: The subject of this chapter is ADAM10, myelin-associated metalloendopeptidase. ADAM10 is a zinc-dependent metallo-endopeptidase with a C-terminal distintegrin domain. It is a homolog of adamalysin. As an α-secretase, it is protective against Alzheimer’s disease, cleaving the Aβ protein so that the damaging β-secretase cleavage is reduced. ADAM10 is a sheddase and releases soluble ectodomains from a variety of membrane-bound proteins including cadherins. Unusually, in the precursor, the C-terminus blocks the active site. Interactions with different tetraspanins affect activation and substrate specificity.

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Contributing Institute(s):

1. Rostock / Greifswald common (Rostock / Greifswald common)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

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