TY  - CHAP
AU  - Postina, Rolf
AU  - Fahrenholz, Falk
TI  - ADAM10, myelin-associated metalloendopeptidase
PB  - Elsevier
M1  - DZNE-2025-01439
SP  - 1185 - 1194
PY  - 2025
AB  - The subject of this chapter is ADAM10, myelin-associated metalloendopeptidase. ADAM10 is a zinc-dependent metallo-endopeptidase with a C-terminal distintegrin domain. It is a homolog of adamalysin. As an α-secretase, it is protective against Alzheimer’s disease, cleaving the Aβ protein so that the damaging β-secretase cleavage is reduced. ADAM10 is a sheddase and releases soluble ectodomains from a variety of membrane-bound proteins including cadherins. Unusually, in the precursor, the C-terminus blocks the active site. Interactions with different tetraspanins affect activation and substrate specificity.
LB  - PUB:(DE-HGF)7
DO  - DOI:10.1016/B978-0-443-28849-4.00185-5
UR  - https://pub.dzne.de/record/283027
ER  -