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@INBOOK{Postina:283027,
      author       = {Postina, Rolf and Fahrenholz, Falk},
      title        = {{ADAM}10, myelin-associated metalloendopeptidase},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-01439},
      pages        = {1185 - 1194},
      year         = {2025},
      comment      = {Handbook of Proteolytic Enzymes / Postina, Rolf ; :
                      Elsevier, 2025, ; ISBN: 9780443288494 ;
                      doi:10.1016/B978-0-443-28849-4.00185-5},
      booktitle     = {Handbook of Proteolytic Enzymes /
                       Postina, Rolf ; : Elsevier, 2025, ;
                       ISBN: 9780443288494 ;
                       doi:10.1016/B978-0-443-28849-4.00185-5},
      abstract     = {The subject of this chapter is ADAM10, myelin-associated
                      metalloendopeptidase. ADAM10 is a zinc-dependent
                      metallo-endopeptidase with a C-terminal distintegrin domain.
                      It is a homolog of adamalysin. As an α-secretase, it is
                      protective against Alzheimer’s disease, cleaving the Aβ
                      protein so that the damaging β-secretase cleavage is
                      reduced. ADAM10 is a sheddase and releases soluble
                      ectodomains from a variety of membrane-bound proteins
                      including cadherins. Unusually, in the precursor, the
                      C-terminus blocks the active site. Interactions with
                      different tetraspanins affect activation and substrate
                      specificity.},
      cin          = {Rostock / Greifswald common},
      cid          = {I:(DE-2719)6000017},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)7},
      doi          = {10.1016/B978-0-443-28849-4.00185-5},
      url          = {https://pub.dzne.de/record/283027},
}