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| 001 | 283027 | ||
| 005 | 20251222102632.0 | ||
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| 037 | _ | _ | |a DZNE-2025-01439 |
| 041 | _ | _ | |a English |
| 100 | 1 | _ | |a Postina, Rolf |b 0 |
| 245 | _ | _ | |a ADAM10, myelin-associated metalloendopeptidase |
| 260 | _ | _ | |c 2025 |b Elsevier |
| 295 | 1 | 0 | |a Handbook of Proteolytic Enzymes / Postina, Rolf ; : Elsevier, 2025, ; ISBN: 9780443288494 ; doi:10.1016/B978-0-443-28849-4.00185-5 |
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| 520 | _ | _ | |a The subject of this chapter is ADAM10, myelin-associated metalloendopeptidase. ADAM10 is a zinc-dependent metallo-endopeptidase with a C-terminal distintegrin domain. It is a homolog of adamalysin. As an α-secretase, it is protective against Alzheimer’s disease, cleaving the Aβ protein so that the damaging β-secretase cleavage is reduced. ADAM10 is a sheddase and releases soluble ectodomains from a variety of membrane-bound proteins including cadherins. Unusually, in the precursor, the C-terminus blocks the active site. Interactions with different tetraspanins affect activation and substrate specificity. |
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| 700 | 1 | _ | |a Fahrenholz, Falk |0 P:(DE-HGF)0 |b 1 |e Last author |
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