%0 Journal Article
%A Siewert, Lena K
%A Berve, Kristina
%A Pössnecker, Elisabeth
%A Dyckow, Julia
%A Zulji, Amel
%A Baumann, Ryan
%A Munoz-Blazquez, Aida
%A Krishnamoorthy, Gurumoorthy
%A Schreiner, David
%A Sagan, Sharon
%A Nelson, Charlotte
%A Sabatino, Joseph J
%A Nagashima, Kazuki
%A Diard, Médéric
%A J Macpherson, Andrew
%A Ganal-Vonarburg, Stephanie C
%A Fischbach, Michael A
%A Zamvil, Scott S
%A Schirmer, Lucas
%A Baranzini, Sergio E
%A Pröbstel, Anne-Katrin
%T Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.
%J Gut microbes
%V 18
%N 1
%@ 1949-0976
%C Austin, Tex.
%I Landes Bioscience
%M DZNE-2025-01497
%P 2601430
%D 2026
%X Microbiome-based therapies are promising new treatment avenues. While global alterations in microbiota composition have been shown in multiple sclerosis, whether and how gut microbiota influence autoimmune responses in an antigen-specific manner is unclear. Here, we genetically engineered gut bacteria to express a brain antigen and dissect their pathogenic potential in a murine model of autoimmune neuroinflammation. Colonization with bacteria expressing myelin - but not ovalbumin-peptide exacerbates an encephalitogenic immune response in the gut by activating antigen-specific T cells as well as B cells leading to accelerated neuroinflammatory disease. These results demonstrate how antigen-specific microbial modulation can influence autoimmunity, providing insight for development of therapeutic strategies targeting specific bacterial taxa for treatment of MS and other autoimmune diseases.
%K Animals
%K Gastrointestinal Microbiome: immunology
%K Mice
%K Encephalomyelitis, Autoimmune, Experimental: immunology
%K Encephalomyelitis, Autoimmune, Experimental: microbiology
%K Mice, Inbred C57BL
%K T-Lymphocytes: immunology
%K B-Lymphocytes: immunology
%K Disease Models, Animal
%K Neuroinflammatory Diseases: immunology
%K Neuroinflammatory Diseases: microbiology
%K Multiple Sclerosis: immunology
%K Multiple Sclerosis: microbiology
%K Autoimmunity
%K Bacteria: genetics
%K Bacteria: immunology
%K Female
%K Antigens: immunology
%K Microbiome (Other)
%K mucosal immunology (Other)
%K multiple sclerosis (Other)
%K neuroinflammation (Other)
%K Antigens (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41437842
%R 10.1080/19490976.2025.2601430
%U https://pub.dzne.de/record/283090