Journal Article

DZNE-2025-01497

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.

Siewert, L. K. ; Berve, K. ; Pössnecker, E. ; Dyckow, J. ; Zulji, A. ; Baumann, R. ; Munoz-Blazquez, A. ; Krishnamoorthy, G.DZNE* ; Schreiner, D. ; Sagan, S. ; Nelson, C. ; Sabatino, J. J. ; Nagashima, K. ; Diard, M. ; J Macpherson, A. ; Ganal-Vonarburg, S. C. ; Fischbach, M. A. ; Zamvil, S. S. ; Schirmer, L. ; Baranzini, S. E. ; Pröbstel, A.-K. (Last author)DZNE*

2026
Landes Bioscience Austin, Tex.

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Please use a persistent id in citations: doi:10.1080/19490976.2025.2601430

Abstract: Microbiome-based therapies are promising new treatment avenues. While global alterations in microbiota composition have been shown in multiple sclerosis, whether and how gut microbiota influence autoimmune responses in an antigen-specific manner is unclear. Here, we genetically engineered gut bacteria to express a brain antigen and dissect their pathogenic potential in a murine model of autoimmune neuroinflammation. Colonization with bacteria expressing myelin - but not ovalbumin-peptide exacerbates an encephalitogenic immune response in the gut by activating antigen-specific T cells as well as B cells leading to accelerated neuroinflammatory disease. These results demonstrate how antigen-specific microbial modulation can influence autoimmunity, providing insight for development of therapeutic strategies targeting specific bacterial taxa for treatment of MS and other autoimmune diseases.

Keyword(s): Animals (MeSH) ; Gastrointestinal Microbiome: immunology (MeSH) ; Mice (MeSH) ; Encephalomyelitis, Autoimmune, Experimental: immunology (MeSH) ; Encephalomyelitis, Autoimmune, Experimental: microbiology (MeSH) ; Mice, Inbred C57BL (MeSH) ; T-Lymphocytes: immunology (MeSH) ; B-Lymphocytes: immunology (MeSH) ; Disease Models, Animal (MeSH) ; Neuroinflammatory Diseases: immunology (MeSH) ; Neuroinflammatory Diseases: microbiology (MeSH) ; Multiple Sclerosis: immunology (MeSH) ; Multiple Sclerosis: microbiology (MeSH) ; Autoimmunity (MeSH) ; Bacteria: genetics (MeSH) ; Bacteria: immunology (MeSH) ; Female (MeSH) ; Antigens: immunology (MeSH) ; Microbiome ; mucosal immunology ; multiple sclerosis ; neuroinflammation ; Antigens

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Contributing Institute(s):

1. Clinical Neurology and Neuroimmunology (AG Pröbstel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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