000283090 001__ 283090
000283090 005__ 20251230140444.0
000283090 0247_ $$2doi$$a10.1080/19490976.2025.2601430
000283090 0247_ $$2pmid$$apmid:41437842
000283090 0247_ $$2ISSN$$a1949-0976
000283090 0247_ $$2ISSN$$a1949-0984
000283090 037__ $$aDZNE-2025-01497
000283090 041__ $$aEnglish
000283090 082__ $$a570
000283090 1001_ $$aSiewert, Lena K$$b0
000283090 245__ $$aAntigen-specific activation of gut immune cells drives autoimmune neuroinflammation.
000283090 260__ $$aAustin, Tex.$$bLandes Bioscience$$c2026
000283090 3367_ $$2DRIVER$$aarticle
000283090 3367_ $$2DataCite$$aOutput Types/Journal article
000283090 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1767090427_6286
000283090 3367_ $$2BibTeX$$aARTICLE
000283090 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000283090 3367_ $$00$$2EndNote$$aJournal Article
000283090 520__ $$aMicrobiome-based therapies are promising new treatment avenues. While global alterations in microbiota composition have been shown in multiple sclerosis, whether and how gut microbiota influence autoimmune responses in an antigen-specific manner is unclear. Here, we genetically engineered gut bacteria to express a brain antigen and dissect their pathogenic potential in a murine model of autoimmune neuroinflammation. Colonization with bacteria expressing myelin - but not ovalbumin-peptide exacerbates an encephalitogenic immune response in the gut by activating antigen-specific T cells as well as B cells leading to accelerated neuroinflammatory disease. These results demonstrate how antigen-specific microbial modulation can influence autoimmunity, providing insight for development of therapeutic strategies targeting specific bacterial taxa for treatment of MS and other autoimmune diseases.
000283090 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000283090 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000283090 650_7 $$2Other$$aMicrobiome
000283090 650_7 $$2Other$$amucosal immunology
000283090 650_7 $$2Other$$amultiple sclerosis
000283090 650_7 $$2Other$$aneuroinflammation
000283090 650_7 $$2NLM Chemicals$$aAntigens
000283090 650_2 $$2MeSH$$aAnimals
000283090 650_2 $$2MeSH$$aGastrointestinal Microbiome: immunology
000283090 650_2 $$2MeSH$$aMice
000283090 650_2 $$2MeSH$$aEncephalomyelitis, Autoimmune, Experimental: immunology
000283090 650_2 $$2MeSH$$aEncephalomyelitis, Autoimmune, Experimental: microbiology
000283090 650_2 $$2MeSH$$aMice, Inbred C57BL
000283090 650_2 $$2MeSH$$aT-Lymphocytes: immunology
000283090 650_2 $$2MeSH$$aB-Lymphocytes: immunology
000283090 650_2 $$2MeSH$$aDisease Models, Animal
000283090 650_2 $$2MeSH$$aNeuroinflammatory Diseases: immunology
000283090 650_2 $$2MeSH$$aNeuroinflammatory Diseases: microbiology
000283090 650_2 $$2MeSH$$aMultiple Sclerosis: immunology
000283090 650_2 $$2MeSH$$aMultiple Sclerosis: microbiology
000283090 650_2 $$2MeSH$$aAutoimmunity
000283090 650_2 $$2MeSH$$aBacteria: genetics
000283090 650_2 $$2MeSH$$aBacteria: immunology
000283090 650_2 $$2MeSH$$aFemale
000283090 650_2 $$2MeSH$$aAntigens: immunology
000283090 7001_ $$aBerve, Kristina$$b1
000283090 7001_ $$00000-0002-6271-2404$$aPössnecker, Elisabeth$$b2
000283090 7001_ $$aDyckow, Julia$$b3
000283090 7001_ $$aZulji, Amel$$b4
000283090 7001_ $$aBaumann, Ryan$$b5
000283090 7001_ $$aMunoz-Blazquez, Aida$$b6
000283090 7001_ $$0P:(DE-HGF)0$$aKrishnamoorthy, Gurumoorthy$$b7
000283090 7001_ $$aSchreiner, David$$b8
000283090 7001_ $$aSagan, Sharon$$b9
000283090 7001_ $$aNelson, Charlotte$$b10
000283090 7001_ $$aSabatino, Joseph J$$b11
000283090 7001_ $$aNagashima, Kazuki$$b12
000283090 7001_ $$aDiard, Médéric$$b13
000283090 7001_ $$aJ Macpherson, Andrew$$b14
000283090 7001_ $$aGanal-Vonarburg, Stephanie C$$b15
000283090 7001_ $$aFischbach, Michael A$$b16
000283090 7001_ $$aZamvil, Scott S$$b17
000283090 7001_ $$aSchirmer, Lucas$$b18
000283090 7001_ $$aBaranzini, Sergio E$$b19
000283090 7001_ $$0P:(DE-2719)9003515$$aPröbstel, Anne-Katrin$$b20$$eLast author$$udzne
000283090 773__ $$0PERI:(DE-600)2575755-6$$a10.1080/19490976.2025.2601430$$gVol. 18, no. 1, p. 2601430$$n1$$p2601430$$tGut microbes$$v18$$x1949-0976$$y2026
000283090 8564_ $$uhttps://pub.dzne.de/record/283090/files/DZNE-2025-1497.pdf$$yOpenAccess
000283090 8564_ $$uhttps://pub.dzne.de/record/283090/files/DZNE-2025-1497.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000283090 9101_ $$0I:(DE-588)1065079516$$6P:(DE-HGF)0$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000283090 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9003515$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b20$$kDZNE
000283090 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000283090 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-06
000283090 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000283090 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bGUT MICROBES : 2022$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bGUT MICROBES : 2022$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-08-08T20:21:19Z
000283090 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-08-08T20:21:19Z
000283090 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000283090 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2024-08-08T20:21:19Z
000283090 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-06
000283090 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-06
000283090 9201_ $$0I:(DE-2719)1013045$$kAG Pröbstel$$lClinical Neurology and Neuroimmunology$$x0
000283090 980__ $$ajournal
000283090 980__ $$aVDB
000283090 980__ $$aUNRESTRICTED
000283090 980__ $$aI:(DE-2719)1013045
000283090 9801_ $$aFullTexts