TY  - JOUR
AU  - Siewert, Lena K
AU  - Berve, Kristina
AU  - Pössnecker, Elisabeth
AU  - Dyckow, Julia
AU  - Zulji, Amel
AU  - Baumann, Ryan
AU  - Munoz-Blazquez, Aida
AU  - Krishnamoorthy, Gurumoorthy
AU  - Schreiner, David
AU  - Sagan, Sharon
AU  - Nelson, Charlotte
AU  - Sabatino, Joseph J
AU  - Nagashima, Kazuki
AU  - Diard, Médéric
AU  - J Macpherson, Andrew
AU  - Ganal-Vonarburg, Stephanie C
AU  - Fischbach, Michael A
AU  - Zamvil, Scott S
AU  - Schirmer, Lucas
AU  - Baranzini, Sergio E
AU  - Pröbstel, Anne-Katrin
TI  - Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.
JO  - Gut microbes
VL  - 18
IS  - 1
SN  - 1949-0976
CY  - Austin, Tex.
PB  - Landes Bioscience
M1  - DZNE-2025-01497
SP  - 2601430
PY  - 2026
AB  - Microbiome-based therapies are promising new treatment avenues. While global alterations in microbiota composition have been shown in multiple sclerosis, whether and how gut microbiota influence autoimmune responses in an antigen-specific manner is unclear. Here, we genetically engineered gut bacteria to express a brain antigen and dissect their pathogenic potential in a murine model of autoimmune neuroinflammation. Colonization with bacteria expressing myelin - but not ovalbumin-peptide exacerbates an encephalitogenic immune response in the gut by activating antigen-specific T cells as well as B cells leading to accelerated neuroinflammatory disease. These results demonstrate how antigen-specific microbial modulation can influence autoimmunity, providing insight for development of therapeutic strategies targeting specific bacterial taxa for treatment of MS and other autoimmune diseases.
KW  - Animals
KW  - Gastrointestinal Microbiome: immunology
KW  - Mice
KW  - Encephalomyelitis, Autoimmune, Experimental: immunology
KW  - Encephalomyelitis, Autoimmune, Experimental: microbiology
KW  - Mice, Inbred C57BL
KW  - T-Lymphocytes: immunology
KW  - B-Lymphocytes: immunology
KW  - Disease Models, Animal
KW  - Neuroinflammatory Diseases: immunology
KW  - Neuroinflammatory Diseases: microbiology
KW  - Multiple Sclerosis: immunology
KW  - Multiple Sclerosis: microbiology
KW  - Autoimmunity
KW  - Bacteria: genetics
KW  - Bacteria: immunology
KW  - Female
KW  - Antigens: immunology
KW  - Microbiome (Other)
KW  - mucosal immunology (Other)
KW  - multiple sclerosis (Other)
KW  - neuroinflammation (Other)
KW  - Antigens (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41437842
DO  - DOI:10.1080/19490976.2025.2601430
UR  - https://pub.dzne.de/record/283090
ER  -