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@ARTICLE{Siewert:283090,
      author       = {Siewert, Lena K and Berve, Kristina and Pössnecker,
                      Elisabeth and Dyckow, Julia and Zulji, Amel and Baumann,
                      Ryan and Munoz-Blazquez, Aida and Krishnamoorthy,
                      Gurumoorthy and Schreiner, David and Sagan, Sharon and
                      Nelson, Charlotte and Sabatino, Joseph J and Nagashima,
                      Kazuki and Diard, Médéric and J Macpherson, Andrew and
                      Ganal-Vonarburg, Stephanie C and Fischbach, Michael A and
                      Zamvil, Scott S and Schirmer, Lucas and Baranzini, Sergio E
                      and Pröbstel, Anne-Katrin},
      title        = {{A}ntigen-specific activation of gut immune cells drives
                      autoimmune neuroinflammation.},
      journal      = {Gut microbes},
      volume       = {18},
      number       = {1},
      issn         = {1949-0976},
      address      = {Austin, Tex.},
      publisher    = {Landes Bioscience},
      reportid     = {DZNE-2025-01497},
      pages        = {2601430},
      year         = {2026},
      abstract     = {Microbiome-based therapies are promising new treatment
                      avenues. While global alterations in microbiota composition
                      have been shown in multiple sclerosis, whether and how gut
                      microbiota influence autoimmune responses in an
                      antigen-specific manner is unclear. Here, we genetically
                      engineered gut bacteria to express a brain antigen and
                      dissect their pathogenic potential in a murine model of
                      autoimmune neuroinflammation. Colonization with bacteria
                      expressing myelin - but not ovalbumin-peptide exacerbates an
                      encephalitogenic immune response in the gut by activating
                      antigen-specific T cells as well as B cells leading to
                      accelerated neuroinflammatory disease. These results
                      demonstrate how antigen-specific microbial modulation can
                      influence autoimmunity, providing insight for development of
                      therapeutic strategies targeting specific bacterial taxa for
                      treatment of MS and other autoimmune diseases.},
      keywords     = {Animals / Gastrointestinal Microbiome: immunology / Mice /
                      Encephalomyelitis, Autoimmune, Experimental: immunology /
                      Encephalomyelitis, Autoimmune, Experimental: microbiology /
                      Mice, Inbred C57BL / T-Lymphocytes: immunology /
                      B-Lymphocytes: immunology / Disease Models, Animal /
                      Neuroinflammatory Diseases: immunology / Neuroinflammatory
                      Diseases: microbiology / Multiple Sclerosis: immunology /
                      Multiple Sclerosis: microbiology / Autoimmunity / Bacteria:
                      genetics / Bacteria: immunology / Female / Antigens:
                      immunology / Microbiome (Other) / mucosal immunology (Other)
                      / multiple sclerosis (Other) / neuroinflammation (Other) /
                      Antigens (NLM Chemicals)},
      cin          = {AG Pröbstel},
      ddc          = {570},
      cid          = {I:(DE-2719)1013045},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41437842},
      doi          = {10.1080/19490976.2025.2601430},
      url          = {https://pub.dzne.de/record/283090},
}