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001     283090
005     20251230140444.0
024 7 _ |a 10.1080/19490976.2025.2601430
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037 _ _ |a DZNE-2025-01497
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Siewert, Lena K
|b 0
245 _ _ |a Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.
260 _ _ |a Austin, Tex.
|c 2026
|b Landes Bioscience
336 7 _ |a article
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336 7 _ |a Journal Article
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520 _ _ |a Microbiome-based therapies are promising new treatment avenues. While global alterations in microbiota composition have been shown in multiple sclerosis, whether and how gut microbiota influence autoimmune responses in an antigen-specific manner is unclear. Here, we genetically engineered gut bacteria to express a brain antigen and dissect their pathogenic potential in a murine model of autoimmune neuroinflammation. Colonization with bacteria expressing myelin - but not ovalbumin-peptide exacerbates an encephalitogenic immune response in the gut by activating antigen-specific T cells as well as B cells leading to accelerated neuroinflammatory disease. These results demonstrate how antigen-specific microbial modulation can influence autoimmunity, providing insight for development of therapeutic strategies targeting specific bacterial taxa for treatment of MS and other autoimmune diseases.
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650 _ 7 |a Microbiome
|2 Other
650 _ 7 |a mucosal immunology
|2 Other
650 _ 7 |a multiple sclerosis
|2 Other
650 _ 7 |a neuroinflammation
|2 Other
650 _ 7 |a Antigens
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Gastrointestinal Microbiome: immunology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Encephalomyelitis, Autoimmune, Experimental: immunology
|2 MeSH
650 _ 2 |a Encephalomyelitis, Autoimmune, Experimental: microbiology
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a T-Lymphocytes: immunology
|2 MeSH
650 _ 2 |a B-Lymphocytes: immunology
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: immunology
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: microbiology
|2 MeSH
650 _ 2 |a Multiple Sclerosis: immunology
|2 MeSH
650 _ 2 |a Multiple Sclerosis: microbiology
|2 MeSH
650 _ 2 |a Autoimmunity
|2 MeSH
650 _ 2 |a Bacteria: genetics
|2 MeSH
650 _ 2 |a Bacteria: immunology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Antigens: immunology
|2 MeSH
700 1 _ |a Berve, Kristina
|b 1
700 1 _ |a Pössnecker, Elisabeth
|0 0000-0002-6271-2404
|b 2
700 1 _ |a Dyckow, Julia
|b 3
700 1 _ |a Zulji, Amel
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700 1 _ |a Baumann, Ryan
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700 1 _ |a Munoz-Blazquez, Aida
|b 6
700 1 _ |a Krishnamoorthy, Gurumoorthy
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700 1 _ |a Schreiner, David
|b 8
700 1 _ |a Sagan, Sharon
|b 9
700 1 _ |a Nelson, Charlotte
|b 10
700 1 _ |a Sabatino, Joseph J
|b 11
700 1 _ |a Nagashima, Kazuki
|b 12
700 1 _ |a Diard, Médéric
|b 13
700 1 _ |a J Macpherson, Andrew
|b 14
700 1 _ |a Ganal-Vonarburg, Stephanie C
|b 15
700 1 _ |a Fischbach, Michael A
|b 16
700 1 _ |a Zamvil, Scott S
|b 17
700 1 _ |a Schirmer, Lucas
|b 18
700 1 _ |a Baranzini, Sergio E
|b 19
700 1 _ |a Pröbstel, Anne-Katrin
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773 _ _ |a 10.1080/19490976.2025.2601430
|g Vol. 18, no. 1, p. 2601430
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|t Gut microbes
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|y 2026
|x 1949-0976
856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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