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000283138 1001_ $$0P:(DE-2719)9001347$$aBenoit, Chloé Maëlle$$b0$$eFirst author
000283138 245__ $$aAxon initial segment dynamics during associative fear learning
000283138 260__ $$aNew York, NY$$bNature America$$c2026
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000283138 520__ $$aThe axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.
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000283138 7001_ $$0P:(DE-2719)9001367$$aGanea, Dan Alin$$b1$$eFirst author
000283138 7001_ $$0P:(DE-2719)9002046$$aParicio-Montesinos, Ricardo$$b2
000283138 7001_ $$0P:(DE-2719)2812406$$aEsser, Julia$$b3
000283138 7001_ $$00000-0002-3344-8683$$aThome, Christian$$b4
000283138 7001_ $$0P:(DE-HGF)0$$aJanssen, Jan Maximilian$$b5
000283138 7001_ $$00000-0002-1345-2204$$aSattin, Andrea$$b6
000283138 7001_ $$0P:(DE-HGF)0$$aInnocenti, Sabrina Milena$$b7
000283138 7001_ $$0P:(DE-2719)9001056$$aKrabbe, Sabine$$b8
000283138 7001_ $$00000-0002-1859-4252$$aLüthi, Andreas$$b9
000283138 7001_ $$00000-0003-2718-7533$$aFellin, Tommaso$$b10
000283138 7001_ $$0P:(DE-HGF)0$$aEngelhardt, Maren$$b11
000283138 7001_ $$0P:(DE-2719)9001219$$aGründemann, Jan$$b12$$eLast author
000283138 773__ $$0PERI:(DE-600)1494955-6$$a10.1038/s41593-025-02152-5$$p1-24$$tNature neuroscience$$vAdvance online publication$$x1097-6256$$y2026
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