Journal Article

DZNE-2026-00034

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Axon initial segment dynamics during associative fear learning

Benoit, C. M. (First author)DZNE* ; Ganea, D. A. (First author)DZNE* ; Paricio-Montesinos, R.DZNE* ; Esser, J.DZNE* ; Thome, C. ; Janssen, J. M. ; Sattin, A. ; Innocenti, S. M. ; Krabbe, S.DZNE* ; Lüthi, A. ; Fellin, T. ; Engelhardt, M. ; Gründemann, J. (Last author)DZNE*

2026
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/s41593-025-02152-5

Abstract: The axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.

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Contributing Institute(s):

1. Neural Circuit Computations (AG Gründemann)
2. Functional Diversity of Neural Circuits (AG Krabbe)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Experiment(s):

1. Light Microscope Facility (CRFS-LMF) / Bonn

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Nature ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 25 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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