TY  - JOUR
AU  - Benoit, Chloé Maëlle
AU  - Ganea, Dan Alin
AU  - Paricio-Montesinos, Ricardo
AU  - Esser, Julia
AU  - Thome, Christian
AU  - Janssen, Jan Maximilian
AU  - Sattin, Andrea
AU  - Innocenti, Sabrina Milena
AU  - Krabbe, Sabine
AU  - Lüthi, Andreas
AU  - Fellin, Tommaso
AU  - Engelhardt, Maren
AU  - Gründemann, Jan
TI  - Axon initial segment dynamics during associative fear learning
JO  - Nature neuroscience
VL  - Advance online publication
SN  - 1097-6256
CY  - New York, NY
PB  - Nature America
M1  - DZNE-2026-00034
SP  - 1-24
PY  - 2026
AB  - The axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1038/s41593-025-02152-5
UR  - https://pub.dzne.de/record/283138
ER  -