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@ARTICLE{Benoit:283138,
author = {Benoit, Chloé Maëlle and Ganea, Dan Alin and
Paricio-Montesinos, Ricardo and Esser, Julia and Thome,
Christian and Janssen, Jan Maximilian and Sattin, Andrea and
Innocenti, Sabrina Milena and Krabbe, Sabine and Lüthi,
Andreas and Fellin, Tommaso and Engelhardt, Maren and
Gründemann, Jan},
title = {{A}xon initial segment dynamics during associative fear
learning},
journal = {Nature neuroscience},
volume = {Advance online publication},
issn = {1097-6256},
address = {New York, NY},
publisher = {Nature America},
reportid = {DZNE-2026-00034},
pages = {1-24},
year = {2026},
abstract = {The axon initial segment (AIS) is the site of action
potential generation and exhibits structural and functional
plasticity upon adaptation of neuronal excitability and
disease. Performing in vivo longitudinal two-photon imaging
of AIS in the medial prefrontal cortex of male mice, we
reveal dynamic AIS remodeling during associative fear
learning and extinction. These results demonstrate that AIS
plasticity is not only crucial for homeostatic adaptation
but also a hallmark of memory formation.},
cin = {AG Gründemann / AG Krabbe},
ddc = {610},
cid = {I:(DE-2719)5000069 / I:(DE-2719)5000059},
pnm = {351 - Brain Function (POF4-351)},
pid = {G:(DE-HGF)POF4-351},
experiment = {EXP:(DE-2719)LMF-20190308},
typ = {PUB:(DE-HGF)16},
doi = {10.1038/s41593-025-02152-5},
url = {https://pub.dzne.de/record/283138},
}