TY  - JOUR
AU  - Pakeerathan, Thivya
AU  - Davis, James
AU  - Henderson, Amanda D
AU  - Sotirchos, Elias S
AU  - Said, Yana
AU  - Havla, Joachim
AU  - Ringelstein, Marius
AU  - Aktas, Orhan
AU  - Weise, Margit
AU  - Gernert, Jonathan A
AU  - Kornek, Barbara
AU  - Bsteh, Gabriel
AU  - Rommer, Paulus S
AU  - Krajnc, Nik
AU  - Pröbstel, Anne-Katrin
AU  - Papadopoulou, Athina
AU  - Kulsvehagen, Laila
AU  - Pretzsch, Roxanne
AU  - Schoenholzer, Kean
AU  - Padungkiatsagul, Tanyatuth
AU  - Moss, Heather E
AU  - Villarreal Navarro, Sylvia E
AU  - Herwerth, Marina
AU  - Graure, Madalina
AU  - Kana, Veronika
AU  - Stiebel-Kalish, Hadas
AU  - Zlatkin, Rita
AU  - Arnold, Anthony C
AU  - Bonelli, Laura
AU  - Stellmann, Jan-Patrick
AU  - Stolowy, Natacha
AU  - Schwake, Carolin
AU  - Schneider-Gold, Christiane
AU  - Kümpfel, Tania
AU  - Albrecht, Philipp
AU  - Rattanathamsakul, Natthapon
AU  - Pittock, Sean J
AU  - Flanagan, Eoin P
AU  - Carta, Sara
AU  - Mariotto, Sara
AU  - Gold, Ralf
AU  - Chen, John J
AU  - Ayzenberg, Ilya
TI  - OCT-Based Differentiation of First Acute Optic Neuritis: An International Study of 111 Patients With NMOSD and MOGAD.
JO  - Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
VL  - 13
IS  - 2
SN  - 2332-7812
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2026-00047
SP  - e200531
PY  - 2026
AB  - Severe optic neuritis (ON) is a common clinical manifestation in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD). Given distinct prognoses and often the necessity of early plasma exchange in NMOSD, prompt differentiation is crucial. In this study, we investigated the utility of optical coherence tomography (OCT) in differentiating between first acute NMOSD-ON and MOGAD-associated optic neuritis (MOGAD-ON), as well as specific factors associated with disc edema.In this retrospective multicenter study, 111 adult patients with MOGAD or aquaporin-4 antibody-positive NMOSD who experienced a first ON and underwent OCT within 2 weeks of symptom onset were included from 14 centers across 8 countries. Peripapillary retinal nerve fiber layer (pRNFL) thickness in µm was analyzed, including the average of both eyes in cases of bilateral manifestation.Eighty-three patients with MOGAD (51 women; 124 ON eyes; bilateral ON 48.2
KW  - Humans
KW  - Tomography, Optical Coherence: methods
KW  - Female
KW  - Optic Neuritis: diagnostic imaging
KW  - Optic Neuritis: diagnosis
KW  - Male
KW  - Adult
KW  - Neuromyelitis Optica: diagnosis
KW  - Neuromyelitis Optica: diagnostic imaging
KW  - Middle Aged
KW  - Retrospective Studies
KW  - Diagnosis, Differential
KW  - Myelin-Oligodendrocyte Glycoprotein: immunology
KW  - Young Adult
KW  - Aquaporin 4: immunology
KW  - Aged
KW  - Autoantibodies
KW  - Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
KW  - Myelin-Oligodendrocyte Glycoprotein (NLM Chemicals)
KW  - Aquaporin 4 (NLM Chemicals)
KW  - Autoantibodies (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41499724
DO  - DOI:10.1212/NXI.0000000000200531
UR  - https://pub.dzne.de/record/283151
ER  -