Journal Article

DZNE-2026-00047

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png OCT-Based Differentiation of First Acute Optic Neuritis: An International Study of 111 Patients With NMOSD and MOGAD.

Pakeerathan, T. ; Davis, J. ; Henderson, A. D. ; Sotirchos, E. S. ; Said, Y. ; Havla, J. ; Ringelstein, M. ; Aktas, O. ; Weise, M. ; Gernert, J. A. ; Kornek, B. ; Bsteh, G. ; Rommer, P. S. ; Krajnc, N. ; Pröbstel, A.-K.DZNE* ; Papadopoulou, A. ; Kulsvehagen, L. ; Pretzsch, R. ; Schoenholzer, K. ; Padungkiatsagul, T. ; Moss, H. E. ; Villarreal Navarro, S. E. ; Herwerth, M. ; Graure, M. ; Kana, V. ; Stiebel-Kalish, H. ; Zlatkin, R. ; Arnold, A. C. ; Bonelli, L. ; Stellmann, J.-P. ; Stolowy, N. ; Schwake, C. ; Schneider-Gold, C. ; Kümpfel, T. ; Albrecht, P. ; Rattanathamsakul, N. ; Pittock, S. J. ; Flanagan, E. P. ; Carta, S. ; Mariotto, S. ; Gold, R. ; Chen, J. J. ; Ayzenberg, I.

2026
Wolters Kluwer Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1212/NXI.0000000000200531

Abstract: Severe optic neuritis (ON) is a common clinical manifestation in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD). Given distinct prognoses and often the necessity of early plasma exchange in NMOSD, prompt differentiation is crucial. In this study, we investigated the utility of optical coherence tomography (OCT) in differentiating between first acute NMOSD-ON and MOGAD-associated optic neuritis (MOGAD-ON), as well as specific factors associated with disc edema.In this retrospective multicenter study, 111 adult patients with MOGAD or aquaporin-4 antibody-positive NMOSD who experienced a first ON and underwent OCT within 2 weeks of symptom onset were included from 14 centers across 8 countries. Peripapillary retinal nerve fiber layer (pRNFL) thickness in µm was analyzed, including the average of both eyes in cases of bilateral manifestation.Eighty-three patients with MOGAD (51 women; 124 ON eyes; bilateral ON 48.2%) and 28 with NMOSD (24 women; 36 ON eyes; bilateral ON 21.4%) were enrolled. A significant increase in pRNFL thickness (>2SD), suggestive of disc edema, was observed in 73.4% of MOGAD-ON eyes and 11.1% of NMOSD-ON eyes (p < 0.001). The pRNFL thickness cutoff of 117.5 µm provided 92.9% specificity and 71.1% sensitivity in distinguishing between MOGAD-ON and NMOSD-ON (area under the curve = 0.838). There was no association between pRNFL thickening and MOG-IgG titer (high vs low), body mass index, or the delay between ON onset and OCT. Simultaneous bilateral MOGAD-ON was associated with significantly more pronounced pRNFL thickening.Acute-stage OCT contributes to the rapid and accurate differentiation between MOGAD-ON and NMOSD-ON prior to antibody confirmation, which can be critical for timely therapeutic decisions.

Keyword(s): Humans (MeSH) ; Tomography, Optical Coherence: methods (MeSH) ; Female (MeSH) ; Optic Neuritis: diagnostic imaging (MeSH) ; Optic Neuritis: diagnosis (MeSH) ; Male (MeSH) ; Adult (MeSH) ; Neuromyelitis Optica: diagnosis (MeSH) ; Neuromyelitis Optica: diagnostic imaging (MeSH) ; Middle Aged (MeSH) ; Retrospective Studies (MeSH) ; Diagnosis, Differential (MeSH) ; Myelin-Oligodendrocyte Glycoprotein: immunology (MeSH) ; Young Adult (MeSH) ; Aquaporin 4: immunology (MeSH) ; Aged (MeSH) ; Autoantibodies (MeSH) ; Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MeSH) ; Myelin-Oligodendrocyte Glycoprotein ; Aquaporin 4 ; Autoantibodies

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Contributing Institute(s):

1. Clinical Neurology and Neuroimmunology (AG Pröbstel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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