Journal Article (Review Article)

DZNE-2026-00075

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetisch informierte Therapie in der Psychiatrie: neue Dynamik durch APOE und Antikörpertherapie der Alzheimer-Krankheit | Genetically informed treatment in psychiatry: new dynamics through APOE and antibody treatment of Alzheimer's disease

Müller, D. J. ; Freitag, C. M. ; Heilbronner, U. ; Nöthen, M. M. ; Perneczky, R.DZNE* ; Rietschel, M. ; Schulte, E. C. ; Deckert, J. ; Referat Genetische, m. u. z. N. d. D. (Collaboration Author)

2026
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00115-025-01839-1

Abstract: The European Medicines Agency has recommended testing for the ApoE-genotype prior to treatment of Alzheimer's disease with Lecanemab. The drug approval is limited to patients who are not homozygous for the ApoE epsilon 4 allele. This is to reduce the risk of undesired adverse effects in the patients treated with Lecanemab. With this recommendation for the first time a psychiatric therapy will be genetically informed.

Keyword(s): Alzheimer Disease: genetics (MeSH) ; Alzheimer Disease: drug therapy (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Humans (MeSH) ; Antibodies, Monoclonal, Humanized: therapeutic use (MeSH) ; Antibodies, Monoclonal, Humanized: adverse effects (MeSH) ; Genetic Testing: methods (MeSH) ; Genetic Predisposition to Disease: genetics (MeSH) ; Apolipoproteins E: genetics (MeSH) ; ApoE-genotype ; Adverse effects ; Alzheimer disease ; Lecanemab ; Medication safety ; Antibodies, Monoclonal, Humanized ; Apolipoproteins E

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Contributing Institute(s):

1. Vascular Cognitive Impairment & Post-Stroke Dementia (AG Dichgans)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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