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@ARTICLE{Niedworok:285025,
      author       = {Niedworok, Patrizia and Ciliberti, Rossella Erminia and
                      Xie, Beijia and Mathew, Amal John and Jussila, Benjamin and
                      Lawson, Jennifer A and De Domenico, Elena and Paulusch,
                      Stefan and Beyer, Marc and Nicotera, Pierluigi and Aziz, N
                      Ahmad and Ehninger, Dan and Blaess, Sandra and Bano,
                      Daniele},
      title        = {{BCL}-11 enables adaptive stress responses to environmental
                      challenges.},
      journal      = {iScience},
      volume       = {29},
      number       = {2},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DZNE-2026-00150},
      pages        = {114422},
      year         = {2026},
      abstract     = {Insulin/IGF-1 signaling (IIS) is a master regulator of
                      metabolism, stress resilience, and cell homeostasis in
                      multicellular organisms. In the nematode Caenorhabditis
                      elegans, DAF-2 regulates dauer diapause, animal growth, and
                      lifespan extension in a DAF-16/FOXO-dependent manner. Here
                      we investigated IIS in animals expressing pathogenic
                      variants of BCL-11, an evolutionarily conserved
                      transcription factor that has been implicated in human
                      neurodevelopmental disorders. We found that hypomorphic
                      bcl-11 mutations have a limited impact on C. elegans growth
                      and survival under standard growth conditions. On the
                      contrary, BCL-11 deficiency compromises the cytoprotective
                      properties of daf-2 signaling upon animal exposure to
                      stress. During embryonic development, daf-16 loss of
                      function rescues egg hatching defects in daf-2;bcl-11
                      mutants, suggesting a transcriptional interplay between
                      BCL-11 and DAF-16 in IIS-deficient animals. Together, our
                      data suggest that BCL-11 actively regulates transcription
                      during development, while in adult animals it is recruited
                      in response to environmental insults to enhance stress
                      resilience.},
      keywords     = {biological sciences (Other) / cell biology (Other) / health
                      sciences (Other) / molecular biology (Other)},
      cin          = {AG Bano / AG Schultze / AG Beyer / AG Aziz / AG Ehninger /
                      PRECISE},
      ddc          = {050},
      cid          = {I:(DE-2719)1013003 / I:(DE-2719)1013038 /
                      I:(DE-2719)1013035 / I:(DE-2719)5000071 / I:(DE-2719)1013005
                      / I:(DE-2719)1013031},
      pnm          = {351 - Brain Function (POF4-351) / 354 - Disease Prevention
                      and Healthy Aging (POF4-354) / 352 - Disease Mechanisms
                      (POF4-352)},
      pid          = {G:(DE-HGF)POF4-351 / G:(DE-HGF)POF4-354 /
                      G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41641102},
      pmc          = {pmc:PMC12865584},
      doi          = {10.1016/j.isci.2025.114422},
      url          = {https://pub.dzne.de/record/285025},
}