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@ARTICLE{Planert:285048,
      author       = {Planert, Henrike and Mittermaier, Franz Xaver and Grosser,
                      Sabine and Fidzinski, Pawel and Schneider, Ulf Christoph and
                      Radbruch, Helena and Onken, Julia and Holtkamp, Martin and
                      Schmitz, Dietmar and Alle, Henrik and Vida, Imre and Geiger,
                      Jörg Rolf Paul and Peng, Yangfan},
      title        = {{E}lectrophysiological classification of human layer 2-3
                      pyramidal neurons reveals subtype-specific synaptic
                      interactions.},
      journal      = {Nature neuroscience},
      volume       = {29},
      number       = {2},
      issn         = {1097-6256},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DZNE-2026-00172},
      pages        = {455 - 466},
      year         = {2026},
      abstract     = {Understanding the functional principles of the human brain
                      requires deep insight into its neuronal and network
                      physiology. In superficial layers of temporal cortex,
                      molecular and morphological subtypes of glutamatergic
                      excitatory pyramidal neurons have been described, but
                      subtyping based on electrophysiological parameters has not
                      been performed. The extent to which pyramidal neuron
                      subtypes contribute to the specialization of physiological
                      interactions by forming synaptic subnetworks remains
                      unclear. Here we performed whole-cell patch-clamp recordings
                      of more than 1,400 layer 2-3 (L2-3) pyramidal neurons and
                      1,400 identified monosynaptic connections in acute slices of
                      human temporal cortex. We extract principles of neuronal and
                      synaptic physiology along with anatomy and functional
                      synaptic connectivity. We also show robust classification of
                      pyramidal neurons into four electrophysiological subtypes,
                      corroborated by differences in morphology and decipher
                      subtype-specific synaptic interactions. Principles of
                      microcircuit organization are found to be conserved at the
                      individual level. Such a fine network structure suggests
                      that the functional diversity of pyramidal neurons
                      translates into differential computations within the L2-3
                      microcircuit of the human cortex.},
      keywords     = {Humans / Pyramidal Cells: physiology / Pyramidal Cells:
                      classification / Pyramidal Cells: cytology / Synapses:
                      physiology / Patch-Clamp Techniques / Temporal Lobe:
                      physiology / Temporal Lobe: cytology / Male / Female / Adult
                      / Nerve Net: physiology / Middle Aged},
      cin          = {AG Schmitz},
      ddc          = {610},
      cid          = {I:(DE-2719)1810004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41372679},
      pmc          = {pmc:PMC12880919},
      doi          = {10.1038/s41593-025-02134-7},
      url          = {https://pub.dzne.de/record/285048},
}