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@ARTICLE{Sannemann:286091,
      author       = {Sannemann, Lena and Gerards, Michelle and Bohr, Lara and
                      Brosseron, Frederic and Escher, Claus and Kalthegener,
                      Franziska and Müller, Theresa and Ramírez, Alfredo and
                      Zeyen, Philip and Jessen, Frank and Rostamzadeh, Ayda},
      title        = {{D}ementia risk factor assessment in a local {A}lzheimer's
                      prevention population: a {G}erman cross-sectional,
                      observational study.},
      journal      = {The journal of prevention of Alzheimer's disease},
      volume       = {13},
      number       = {6},
      issn         = {2274-5807},
      address      = {[Paris]},
      publisher    = {Elsevier Masson SAS},
      reportid     = {DZNE-2026-00387},
      pages        = {100556},
      year         = {2026},
      abstract     = {The risk for dementia is to a significant extent driven by
                      potentially modifiable factors. Prevention strategies are
                      increasingly aiming at individually tailored risk reduction
                      approaches, particularly in light of emerging Brain Health
                      Services for dementia prevention (dBHS).The cross-sectional
                      observational study 'Individual Risk Profiling for
                      Alzheimer's and Dementia Prevention' (INSPIRATION) assessed
                      the individual risk factors of 162 participants of the local
                      Cologne Alzheimer Prevention Registry and provided
                      individual feedback on risk profiles during a single visit.
                      We analysed the frequency and patterns of risk factors and
                      explored their association with cognition and Alzheimer's
                      disease (AD) plasma biomarkers.The most common risk factors
                      in this population were obesity, non-adherence to a
                      Mediterranean diet, low subjective sleep quality, subjective
                      experience of stress, and hearing impairment. A principal
                      component analysis (PCA) revealed six principal components
                      (PC), which we labeled as (1) psychosocial factors, (2)
                      blood pressure, (3) physical condition, (4) hearing
                      impairment, (5) lifestyle, and (6) substance use. We found
                      isolated associations between PCs, cognition, and AD plasma
                      biomarkers.These findings provide initial insights into
                      which risk factors may be most relevant and actionable for
                      highly-educated and prevention-motivated populations likely
                      to seek dBHS. Interventions addressing the domains of
                      psychosocial factors, physical condition, and lifestyle may
                      be particularly relevant to consider for a personally
                      tailored risk reduction approach in comparable
                      populations.The study was funded by research funds of the
                      Medical Faculty and the University Hospital Cologne,
                      University of Cologne and the non-profit association Kölner
                      Verein für seelische Gesundheit e.V.},
      keywords     = {Alzheimer’s disease (Other) / Dementia (Other) /
                      Modifiable risk factors (Other) / Prevention (Other) / Risk
                      assessment (Other) / Risk communication (Other)},
      cin          = {AG Heneka / AG Jessen / Clinical Research (Bonn) / Patient
                      Studies (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)1011303 / I:(DE-2719)1011102 /
                      I:(DE-2719)1011001 / I:(DE-2719)1011101},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41935406},
      doi          = {10.1016/j.tjpad.2026.100556},
      url          = {https://pub.dzne.de/record/286091},
}