Journal Article

DZNE-2026-00387

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dementia risk factor assessment in a local Alzheimer's prevention population: a German cross-sectional, observational study.

Sannemann, L. ; Gerards, M.Extern* ; Bohr, L. ; Brosseron, F.DZNE* ; Escher, C.DZNE* ; Kalthegener, F. ; Müller, T. ; Ramírez, A.DZNE* ; Zeyen, P. ; Jessen, F.DZNE* ; Rostamzadeh, A.

2026
Elsevier Masson SAS [Paris]

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Please use a persistent id in citations: doi:10.1016/j.tjpad.2026.100556

Abstract: The risk for dementia is to a significant extent driven by potentially modifiable factors. Prevention strategies are increasingly aiming at individually tailored risk reduction approaches, particularly in light of emerging Brain Health Services for dementia prevention (dBHS).The cross-sectional observational study 'Individual Risk Profiling for Alzheimer's and Dementia Prevention' (INSPIRATION) assessed the individual risk factors of 162 participants of the local Cologne Alzheimer Prevention Registry and provided individual feedback on risk profiles during a single visit. We analysed the frequency and patterns of risk factors and explored their association with cognition and Alzheimer's disease (AD) plasma biomarkers.The most common risk factors in this population were obesity, non-adherence to a Mediterranean diet, low subjective sleep quality, subjective experience of stress, and hearing impairment. A principal component analysis (PCA) revealed six principal components (PC), which we labeled as (1) psychosocial factors, (2) blood pressure, (3) physical condition, (4) hearing impairment, (5) lifestyle, and (6) substance use. We found isolated associations between PCs, cognition, and AD plasma biomarkers.These findings provide initial insights into which risk factors may be most relevant and actionable for highly-educated and prevention-motivated populations likely to seek dBHS. Interventions addressing the domains of psychosocial factors, physical condition, and lifestyle may be particularly relevant to consider for a personally tailored risk reduction approach in comparable populations.The study was funded by research funds of the Medical Faculty and the University Hospital Cologne, University of Cologne and the non-profit association Kölner Verein für seelische Gesundheit e.V.

Keyword(s): Alzheimer’s disease ; Dementia ; Modifiable risk factors ; Prevention ; Risk assessment ; Risk communication

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Contributing Institute(s):

1. Neuroinflammation, Biomarker (AG Heneka)
2. Clinical Alzheimer’s Disease Research (AG Jessen)
3. Clinical Research Coordination (Clinical Research (Bonn))
4. Patient Studies (Bonn) (Patient Studies (Bonn))

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; DEAL Springer ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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