Dataset

DZNE-2026-00510

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model. Kreye et al, v1

Kreye, J.DZNE* ; Reincke, M.DZNE* ; Kornau, H.-C.DZNE* ; Sanchez Sendin, E.DZNE* ; Dietert, K. ; Wilson, I. A. ; Prüß, H.DZNE*

2020
Mendeley

This record in other databases:  

Please use a persistent id in citations: doi:10.17632/f6tb3csgjt.1

Abstract: The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed characterization of virus-neutralizing antibodies and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. Among 598 human monoclonal antibodies (mAbs) from ten COVID-19 patients, we identified 40 strongly neutralizing mAbs. The most potent mAb CV07-209 neutralized authentic SARS-CoV-2 with IC50 of 3.1 ng/ml. Crystal structures of two mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 Å revealed a direct block of ACE2 attachment. Interestingly, some of the near-germline SARS-CoV-2 neutralizing mAbs reacted with mammalian self-antigens. Prophylactic and therapeutic application of CV07-209 protected hamsters from SARS-CoV-2 infection, weight loss and lung pathology. Our results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection are a promising therapeutic strategy.

Keyword(s): Monoclonals

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Contributing Institute(s):

1. Autoimmune Encephalopathies (AG Prüß)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Kreye, J. (First author)DZNE* ; Reincke, S. M.DZNE* ; Kornau, H.-C.DZNE* ; Sanchez Sendin, E.DZNE* ; Corman, V. M.DZNE* ; Liu, H. ; Yuan, M. ; Wu, N. C. ; Zhu, X. ; Lee, C. D. ; Trimpert, J. ; Höltje, M. ; Dietert, K. ; Stöffler, L. ; von Wardenburg, N. ; van Hoof, S. ; Homeyer, M. A. ; Hoffmann, J. ; Abdelgawad, A. ; Gruber, A. D. ; Bertzbach, L. D. ; Vladimirova, D. ; Li, L. Y. ; Barthel, P. C. ; Skriner, K. ; Hocke, A. C. ; Hippenstiel, S. ; Witzenrath, M. ; Suttorp, N. ; Kurth, F. ; Franke, C. ; Endres, M.DZNE* ; Schmitz, D.DZNE* ; Jeworowski, L. M. ; Richter, A. ; Schmidt, M. L. ; Schwarz, T. ; Müller, M. A. ; Drosten, C. ; Wendisch, D. ; Sander, L. E. ; Osterrieder, N. ; Wilson, I. A. ; Prüss, H. (Last author)DZNE*
A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model.
Cell 183(4), 1058 - 1069.e19 (2020) [10.1016/j.cell.2020.09.049]2020   Files  Fulltext Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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