Contribution to a book

DZNE-2026-00659

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ictal SPECT and Its Value in the Localization of the Seizure-Onset Zone

Van Roost, D. (Editor) ; Schijns, O. E. M. G. (Editor) ; Bitzer, F. ; Schulte, F. L. ; Rüber, T. (Last author)DZNE*

2026
Springer Nature Switzerland Cham

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Please use a persistent id in citations: doi:10.1007/978-3-032-04182-1_7

Abstract: Ictal single-photon emission computed tomography (SPECT) is an imaging technique used to identify the seizure-onset zone (SOZ) in epilepsy patients. It visualizes increased cerebral blood flow near the SOZ through radiopharmaceuticals injected shortly after seizure onset. This chapter outlines the principles and methodology of ictal SPECT, including setup, tracer injection, image acquisition, and evaluation. Although ictal SPECT is resource-intensive and involves radiation exposure, it offers valuable insights for epilepsy surgery. Its validity varies by seizure-onset location, showing higher localization success in temporal lobe epilepsy compared to extratemporal cases. While some studies question its added value in presurgical evaluations, ictal SPECT remains clinically relevant for well-selected individuals, particularly those with inconclusive presurgical findings or MRI-negative results.

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Contributing Institute(s):

1. Clinical Neuroimaging (AG Radbruch)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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