Contribution to a book

DZNE-2026-00830

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Impact of COVID-19 on the brain: Antibodies against brain stem antigens

Lucchese, G. ; Vogelgesang, A. ; Stufano, A. ; Flöel, A. (Last author)DZNE*

2024
Elsevier

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Please use a persistent id in citations: doi:10.1016/B978-0-323-95650-5.00054-9

Abstract: Brain stem involvement was proposed early on during the SARS-CoV-2 pandemic as a possible concurring cause of respiratory failure, given that the virus showed the capability of inducing neurological damage, and additional factors beyond direct pulmonary damage appeared to play a role in the clinical picture. In addition, autoimmune neurological complications of SARS-CoV-2, both acute and chronic, are well documented and COVID-19 appears to be associated with the hyperactivation of the immune system and a cytokine storm, thus resembling other clinical conditions characterized by immune dysregulation and autoantibody production. Recent evidence points to autoimmune antibody-mediated brain stem damage in COVID-19 both in the acute phase of the disease as well as in the long-term chronic sequelae.

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Contributing Institute(s):

1. Dementia Prevention – Mechanisms and Clinical Implementation (AG Flöel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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