Axon initial segment plasticity in neuronal circuit function and memory formation

Gründemann, Jan

doi:10.1016/j.cophys.2026.100981

Journal Article (Review Article)

DZNE-2026-00864

Axon initial segment plasticity in neuronal circuit function and memory formation

Gründemann, J. (First author)DZNE*

2026
Elsevier [Amsterdam]

Current opinion in physiology 49, 100981 (2026) [10.1016/j.cophys.2026.100981]

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Please use a persistent id in citations: doi:10.1016/j.cophys.2026.100981

Abstract: Axon initial segments are the main site of action potential initiation. Since the seminal discoveries by Grubb & Burrone and Kuba et al., which showed that axon initial segment length and location can be dynamically changed, a large number of studies have investigated the role of structural axon initial segment plasticity, particularly in light of homeostatic maintenance of neuronal activity and disease states. Recent advances are now starting to shed light on the role of axon initial segments in neuronal circuit function, as well as learning and memory, opening new avenues to understand axon initial segment plasticity in adaptive neuronal dynamics and behavior in health and disease.

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