Journal Article

DZNE-2026-00870

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cognitive training and promoting a healthy lifestyle in isolated REM sleep behavior disorder: The randomized controlled trial CogTrAiL-RBD.

Ophey, A. ; Röttgen, S. ; Kufer, K.DZNE* ; Pauquet, J. ; Scharfenberg, D. ; Armbrust, P. ; Kammerzell, A. ; Knopf, N. ; Kollath, S. ; Sommer, P. ; Doppler, C. E. J. ; Farrher, E. ; Seger, A. ; Shah, N. J. ; Zopfs, D. ; Reetz, K. ; Fink, G. R. ; Sommerauer, M.DZNE* ; Kalbe, E.

2026
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.71707

Abstract: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal phase of Lewy body diseases and linked to a high risk for cognitive decline. Therefore, iRBD provides a suitable window for early intervention.In the monocentric randomized controlled trial 'Cognitive Training & a Healthy, Active Lifestyle Program for People with Isolated REM Sleep Behaviour Disorder' (CogTrAiL-RBD), the feasibility and behavioral effects of a 5-week digital, adaptive, multidomain cognitive training alongside a module promoting a healthy lifestyle (INT) were compared to a waiting-list control group (CON) in 82 individuals with polysomnography-confirmed iRBD. The primary outcome was change in executive functions at 6 weeks post-allocation (t1) and at 6-month follow-up (t2).For executive functions, we found positive intervention effects for the INT versus CON with a medium effect at t1 (d = 0.500, 95% confidence interval [CI]: 0.221-0.779) and a small effect at t2 (d = 0.397, 95% CI: 0.115-0.679).CogTrAiL-RBD provides initial evidence for the feasibility and potential cognitive benefits of cognitive training within a lifestyle-guidance framework in individuals with iRBD. Its suitability for dementia prevention warrants further investigation.

Keyword(s): Humans (MeSH) ; REM Sleep Behavior Disorder: therapy (MeSH) ; REM Sleep Behavior Disorder: psychology (MeSH) ; Cognitive Training (MeSH) ; Female (MeSH) ; Male (MeSH) ; Healthy Lifestyle (MeSH) ; Aged (MeSH) ; Executive Function: physiology (MeSH) ; Treatment Outcome (MeSH) ; Middle Aged (MeSH) ; Polysomnography (MeSH) ; REM sleep behavior disorder ; brain health ; cognitive training ; lifestyle intervention ; prodromal Parkinson's disease ; secondary dementia prevention

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Contributing Institute(s):

1. Biomarker Parkinson's Disease (AG Wüllner)
2. Digital Biomarkers in Parkinson's disease (AG Sommerauer)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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