Modeling Functions and Pathology of Tau Protein in C. elegans

Fortin, Jessica S.; Pir, Ghulam Jeelani; Mandelkow, Eckhard; Choudhary, Bikash

doi:10.1007/978-1-0716-5234-3_13

Contribution to a book

DZNE-2026-00926

Modeling Functions and Pathology of Tau Protein in C. elegans

Fortin, J. S. (Editor) ; Pir, G. J. ; Choudhary, B. ; Mandelkow, E. (Last author)DZNE*

2026
Springer US New York, NY
ISBN: 978-1-0716-5233-6 (print), 978-1-0716-5234-3 (electronic)

Translational Research Methods for Tauopathies / Fortin, Jessica S. (Editor) ; New York, NY : Springer US, 2026, Chapter 13 ; ISSN: 0893-2336=1940-6045 ; ISBN: 978-1-0716-5233-6=978-1-0716-5234-3 ; doi:10.1007/978-1-0716-5234-3 New York, NY : Springer US, Neuromethods 233, 193 - 214 (2026) [10.1007/978-1-0716-5234-3_13]

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Please use a persistent id in citations: doi:10.1007/978-1-0716-5234-3_13

Abstract: Aggregation of Tau, a microtubule-associated protein, is a hallmark of multiple neurodegenerative disorders collectively termed tauopathies, which include dementia-related diseases like Alzheimer’s disease. Technological advances in genetic engineering have transformed the way we study biology, offering powerful tools to explore fundamental processes and to recapitulate aspects of human disease in animal models in remarkably short time frames. Among these, Caenorhabditis elegans, a tiny, nonparasitic nematode, stands out for its fully mapped neuronal connectome, optical transparency, making it suitable for high-resolution behavioral and cellular analyses. These features offer an excellent platform for investigating mechanisms underlying tauopathies. In this chapter, we present methods for generating C. elegans tauopathy models and detail strategies to assess disease-related changes at behavioral, cellular, and biochemical levels, with the aim of advancing our understanding of Tau-driven neurodegeneration.

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