Books

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2022-11-23
08:35
[DZNE-2022-01667] Book
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REMIND: Music – Movement – Mind. Ein Programm und Übungsmanual zur Gesundheitsförderung im Alter und Vorbeugung von Demenz
Logos Verlag Berlin S110 Seiten ()
REMIND („An Environmental Enrichment Intervention to Prevent Dementia“) ist ein innovatives und wissenschaftlich fundiertes Trainingsprogramm zur Gesundheitsförderung im Alter und zur Vorbeugung von Demenz. In dem Programm werden gezielte Übungen eingesetzt, die aus den drei Kernkomponenten Musik (engl. [...]
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2020-08-25
15:55
[DZNE-2020-01002] Book

Rodent Models of Stroke Second Edition Preface
New York, NY : Humana Press, Neuromethods 120, XII, 338 ()

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2020-02-18
18:08
[DZNE-2020-07506] Book/Journal Article
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Investigating fibrillar aggregates of Tau protein by atomic force microscopy.
Amyloid Proteins / Sigurdsson, Einar M. (Editor) ; Totowa, NJ : Humana Press, 2012, Chapter 12 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-61779-550-3=978-1-61779-551-0 ; doi:10.1007/978-1-61779-551-0 Methods in molecular biology 849, 169-183 () [10.1007/978-1-61779-551-0_12]
Atomic force microscopy (AFM) has been used in numerous studies to visualize and analyze the structure and conformation of biological samples, from single molecules to biopolymers to cells. The possibility to analyze native samples without fixation, staining and in physiological buffer conditions, combined with the sub-nanometer resolution, makes AFM a versatile tool for the analysis of protein aggregation and amyloid structures. [...]

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2020-02-18
17:38
[DZNE-2020-05651] Book/Journal Article (Review Article)

Chromatin Remodeling in Monocyte and Macrophage Activation.
Chromatin Remodelling and Immunity / Schultze, J.L. ; : Elsevier, 2017, ; ISSN: 18761623 ; ISBN: 9780128123928 ; doi:10.1016/bs.apcsb.2016.09.001 Advances in protein chemistry and structural biology 106, 1-15 () [10.1016/bs.apcsb.2016.09.001]
Increasing evidence collected during the last years supports the idea that monocyte and macrophage activation is not only associated with transcriptional changes but also changes in the chromatin landscape. Moreover, the introduction of a multidimensional model of macrophage activation allows a more precise description of monocytes and macrophages under homeostatic and pathophysiological conditions. [...]

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2020-02-18
17:28
[DZNE-2020-05038] Book/Journal Article
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In vivo imaging of mitochondria in intact zebrafish larvae.
Mitochondrial Function / Paquet, Dominik ; : Elsevier, 2014, ; ISSN: 00766879 ; ISBN: 9780128014158 ; doi:10.1016/B978-0-12-801415-8.00009-6 Methods in enzymology 547, 151-164 () [10.1016/B978-0-12-801415-8.00009-6]
Visualizing neuronal mitochondria in a living, intact mammalian organism is a challenge that can be overcome in zebrafish larvae, which are highly accessible for optical imaging and genetic manipulation. Here, we detail an approach to visualize neuronal mitochondria in sensory Rohon-Beard axons, which allows quantitatively measuring mitochondrial shape, dynamics, and transport in vivo. [...]

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2020-02-18
17:07
[DZNE-2020-04656] Book/Journal Article
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Genome Editing in Mice Using TALE Nucleases.
TALENs / Kühn, Ralf (Editor) ; New York, NY : Springer New York, 2016, Chapter 17 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-2931-3=978-1-4939-2932-0 ; doi:10.1007/978-1-4939-2932-0 Methods in molecular biology 1338, 229-243 () [10.1007/978-1-4939-2932-0_17]
Gene engineering for generating targeted mouse mutants is a key technology for biomedical research. Using TALENs as sequence-specific nucleases to induce targeted double-strand breaks, the mouse genome can be directly modified in zygotes in a single step without the need for embryonic stem cells. [...]

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2020-02-18
16:58
[DZNE-2020-04094] Book/Journal Article (Review Article)
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Targeting of ECM molecules and their metabolizing enzymes and receptors for the treatment of CNS diseases.
Brain Extracellular Matrix in Health and Disease / Berezin, Vladimir ; : Elsevier, 2014, ; ISSN: 00796123 ; ISBN: 9780444634863 ; doi:10.1016/B978-0-444-63486-3.00015-3 Progress in brain research 214, 353-388 () [10.1016/B978-0-444-63486-3.00015-3]
Extracellular matrix (ECM) molecules, their receptors at the cell surface, and cell adhesion molecules (CAMs) involved in cell-cell or cell-ECM interactions are implicated in processes related to major diseases of the central nervous system including Alzheimer's disease (AD), epilepsy, schizophrenia, addiction, multiple sclerosis, Parkinson's disease, and cancer. There are multiple strategies for targeting the ECM molecules and their metabolizing enzymes and receptors with antibodies, peptides, glycosaminoglycans, and other natural and synthetic compounds. [...]

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2020-02-18
16:58
[DZNE-2020-04087] Book/Journal Article (Editorial)
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Preface. Brain extracellular matrix in health and disease.
Brain Extracellular Matrix in Health and Disease / Dityatev, Alexander ; : Elsevier, 2014, ; ISSN: 00796123 ; ISBN: 9780444634863 ; doi:10.1016/B978-0-444-63486-3.09998-9 Progress in brain research 214, xiii-xvii () [10.1016/B978-0-444-63486-3.09998-9]

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2020-02-18
16:28
[DZNE-2020-02777] Book/Journal Article (Review Article)
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Neuroprotective and neurotoxic signaling by the prion protein.
Prion Proteins / Tatzelt, Jörg (Editor) ; Berlin, Heidelberg : Springer Berlin Heidelberg, 2012, Chapter 160 ; ISSN: 0340-1022=1436-5049 ; ISBN: 978-3-642-24066-9=978-3-642-24067-6 ; doi:10.1007/978-3-642-24067-6 Topics in current chemistry 305, 101-119 () [10.1007/128_2011_160]
Prion diseases in humans and animals are characterized by progressive neurodegeneration and the formation of infectious particles called prions. Both features are intimately linked to a conformational transition of the cellular prion protein (PrP(C)) into aberrantly folded conformers with neurotoxic and self-replicating activities. [...]

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2020-02-18
16:22
[DZNE-2020-02427] Book/Journal Article (Review Article)
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Transcranial sonography in restless legs syndrome.
Transcranial Sonography in Movement Disorders / Godau, Jana ; : Elsevier, 2010, ; ISSN: 00747742 ; ISBN: 9780123813305 ; doi:10.1016/S0074-7742(10)90015-9 International review of neurobiology 90, 199-215 () [10.1016/S0074-7742(10)90015-9]
Restless legs syndrome (RLS) is one of the most common neurological disorders. The diagnosis is mainly based on the patient's report of the characteristic symptoms and further on the response to dopaminergic treatment. [...]

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