AG Misgeld
Neuronal Cell Biology
Also known as:AG Misgeld; Neuronale Zellbiologie
⇧ M DZNE ⇧
Recent Publications
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Dereddi, R. R. ; Djannatian, M.DZNE* ; Fiore, F. ; Kalita, D. ; Verkest, C. ; Torres, F. B. ; Möbius, W. ; Khodaie, B. ; Ruhwedel, T. ; Alhalaseh, K. ; Schifferer, M.DZNE* ; Wirth, A. ; Hill, A. ; Ottenheijm, R. ; Patrizi, A. ; Kann, O. ; Lechner, S. G. ; Freichel, M. ; Agarwal, A.
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry.
Neuron 114(4), 699 - 723.e11 (2026) [10.1016/j.neuron.2025.11.009]2026
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Heger, L.Extern* ; Gubinelli, F.Extern* ; Huber, A. J. ; Cardona-Alberich, A. ; Rovere, M.Extern* ; Matti, U. ; Müller, S. A.DZNE* ; Nagaraja, S.Extern* ; Jaschkowitz, L. ; Schifferer, M.DZNE* ; Wurst, W.DZNE* ; Lichtenthaler, S. F.DZNE* ; Behrends, C. ; Sambandan, S. ; Burbulla, L. F. (Last author)DZNE*
VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.
Science advances 12(7), eadz5645 (2026) [10.1126/sciadv.adz5645]2026
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Todorov-Völgyi, K. ; González-Gallego, J. ; Müller, S. A.DZNE* ; Todorov, M. I. ; Seker, F. B. ; Frerich, S. ; Cernilogar, F. M. ; Schröger, L. ; Malik, R. ; Cao, J. ; Llovera, G. ; Roth, S. ; Schillinger, U. ; Schifferer, M.DZNE* ; Reyahi, A. ; Crusius, D. ; Pedro, L. D. ; Simons, M.DZNE* ; Carlsson, P. ; Ertürk, A. ; Liesz, A. ; Schotta, G. ; Plesnila, N. ; Lichtenthaler, S. F.DZNE* ; Paquet, D. ; Dichgans, M. (Last author)DZNE*
The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling.
Nature neuroscience 29(2), 325 - 336 (2026) [10.1038/s41593-025-02136-5]2026
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González-Gallego, J. ; Todorov-Völgyi, K. ; Müller, S. A.DZNE* ; Antesberger, S. ; Todorov, M. I. ; Malik, R. ; Grimalt-Mirada, R. ; Gonçalves, C. C. ; Schifferer, M.DZNE* ; Kislinger, G.Extern* ; Weisheit, I. ; Lindner, B. ; Crusius, D. ; Kroeger, J. ; Borri, M. ; Erturk, A. ; Nelson, M. ; Misgeld, T.DZNE* ; Lichtenthaler, S. F.DZNE* ; Dichgans, M.DZNE* ; Paquet, D.
A fully iPS-cell-derived 3D model of the human blood-brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions.
Nature neuroscience 29(2), 479 - 492 (2026) [10.1038/s41593-025-02123-w]2026
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Landt, C. ; Held, F. ; Kolotourou, K. ; Guranda, M. ; Vakrakou, A. G. ; Franz, J. ; Thomas, C. ; Schmiedeknecht, M. U. H. ; Bergann, K. ; Wrzos, C. ; Endmayr, V. ; Tsaktanis, T. ; Zechel, S. ; Ancău, M.DZNE* ; Misgeld, T.DZNE* ; Hakroush, S. ; Hametner, S. ; Rothhammer, V. ; Höftberger, R. ; Hemmer, B. ; Stadelmann, C. ; Nessler, S.
Complement C4d Informs the Differential Diagnosis of Inflammatory Demyelinating CNS Diseases.
Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology 13(2), e200528 (2026) [10.1212/NXI.0000000000200528]2026
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Heger, L.Extern* ; Kertess, L. ; Kaufhold, C. M.Extern* ; Gubinelli, F.Extern* ; Cardona-Alberich, A. ; Özata, G. ; Müller, S. A.DZNE* ; Tschirner, S. K.DZNE* ; Stehling, O. ; Schifferer, M.DZNE* ; Peron, C. ; Tiranti, V. ; Lill, R. ; Iuso, A. ; Zecca, L. ; Strupp, M. ; Oertel, W. ; Lichtenthaler, S. F.DZNE* ; Burbulla, L. F. (Last author)DZNE*
Patient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein-Associated Neurodegeneration.
Movement disorders 40(12), 2811 - 2818 (2025) [10.1002/mds.70029]2025
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Simonetti, F. (First author)DZNE* ; Zhong, W. ; Hutten, S. ; Uliana, F. ; Schifferer, M.DZNE* ; Rezaei, A.DZNE* ; Ramirez, L. M.DZNE* ; Hochmair, J.DZNE* ; Sankar, R.DZNE* ; Gopalan, A. ; Kielisch, F. ; Riemenschneider, H.DZNE* ; Ruf, V. ; Schmidt, C. ; Simons, M.DZNE* ; Zweckstetter, M.DZNE* ; Wegmann, S.DZNE* ; Lashley, T. ; Polymenidou, M. ; Edbauer, D.DZNE* ; Dormann, D.
Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.
The EMBO journal 44(24), 7395 - 7433 (2025) [10.1038/s44318-025-00590-2]2025
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Bhattacharya, D.Extern* ; da Silva-Buttkus, P. ; Nalbach, K.DZNE* ; Cheng, L.Extern* ; Garrett, L. ; Irmler, M. ; Kislinger, G.DZNE* ; Werner, G.Extern* ; Rodde, R. ; Lengger, C. ; Beckers, J. ; Zimprich, A. ; Hölter, S. M. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabe de Angelis, M. ; Wefers, B.DZNE* ; Wurst, W.DZNE* ; Brill, M. S. ; Schifferer, M.DZNE* ; Lichtenthaler, S. F.DZNE* ; Behrends, C.
Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia.
Cell death & disease 16(1), 775 (2025) [10.1038/s41419-025-08168-w]2025
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Woo, M. S. ; Brand, J. ; Bal, L. C. ; Moritz, M. ; Walkenhorst, M. ; Vieira, V. ; Ipenberg, I. ; Rothammer, N. ; Wang, M. ; Dogan, B. ; Loreth, D. ; Mayer, C. ; Nagel, D. ; Wagner, I. ; Pfeffer, L. K. ; Landgraf, P. ; van Ham, M. ; Mattern, K. M. ; Winschel, I. ; Frantz, N. ; Sonner, J. K. ; Grosshans, H. K. ; Miguela, A. ; Bauer, S. ; Meurs, N. ; Müller, A. ; Binkle-Ladisch, L. ; Salinas, G. ; Jänsch, L. ; Dieterich, D. C. ; Riedner, M. ; Krüger, E. ; Heppner, F. L.DZNE* ; Glatzel, M. ; Puelles, V. G. ; Engler, J. B. ; Nyengaard, J. R. ; Misgeld, T.DZNE* ; Kerschensteiner, M. ; Merkler, D. ; Meyer-Schwesinger, C. ; Friese, M. A.
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis.
Cell 188(17), 4567 - 4585.e32 (2025) [10.1016/j.cell.2025.05.029]2025
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Gavoci, A. ; Zhiti, A. ; Rusková, M. ; Magiera, M. M. ; Wang, M. ; Ziegler, K. A. ; Hausrat, T. J. ; Ugwuja, A. I. ; Chakraborty, S. ; Engelhardt, S. ; Kneussel, M. ; Balastik, M. ; Janke, C. ; Misgeld, T.DZNE* ; Brill, M. S.
Polyglutamylation of microtubules drives neuronal remodeling.
Nature Communications 16(1), 5384 (2025) [10.1038/s41467-025-60855-6]2025
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All known publications ...
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