Journal Article (Review Article)

DZNE-2020-03109

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png MicroRNAs in age-related diseases.

Dimmeler, S. (Corresponding author) ; Nicotera, P. (Last author)DZNE*

2013
EMBO Press Heidelberg

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Please use a persistent id in citations: doi:10.1002/emmm.201201986

Abstract: Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs. MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns. Many miRNAs appear to be dysregulated during cellular senescence, aging and disease. However, only few miRNAs have been so far linked to age-related changes in cellular and organ functions. The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems.

Keyword(s): Aging: genetics (MeSH) ; Aging: metabolism (MeSH) ; Animals (MeSH) ; Cardiovascular Diseases: genetics (MeSH) ; Cardiovascular Diseases: metabolism (MeSH) ; Humans (MeSH) ; MicroRNAs: genetics (MeSH) ; MicroRNAs: metabolism (MeSH) ; Neurodegenerative Diseases: genetics (MeSH) ; Neurodegenerative Diseases: metabolism (MeSH) ; MicroRNAs

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Contributing Institute(s):

1. Synaptic Connectivity and Neurodegeneration (AG Nicotera)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2013

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Database coverage:
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