Journal Article

DZNE-2020-03353

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Longer telomere length in patients with schizophrenia.

Nieratschker, V. (Corresponding author) ; Lahtinen, J. ; Meier, S. ; Strohmaier, J. ; Frank, J. ; Heinrich, A. ; Breuer, R. ; Witt, S. H. ; Nöthen, M. M.DZNE* ; Rietschel, M. ; Hovatta, I.

2013
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.schres.2013.06.043

Abstract: Previous studies have reported an association between shorter leukocyte telomere length and schizophrenia (SCZ). The aim of the present study was to replicate this finding in a large sample of SCZ patients (n=539) and population-based controls (n=519). In addition, the possible influence of SCZ severity on telomere length - as measured by age of onset, mode of onset, and course of the disorder - was investigated. Telomere length was negatively associated with age in both patients and controls. This is a consistently reported phenomenon, related to the problem of DNA end-replication. However, in contrast to previous findings, SCZ patients displayed longer telomeres compared to controls (p=0.015). No association was found with any SCZ-severity subphenotype. Interestingly, recent studies have reported associations between longer leukocyte telomere length and both smaller hippocampal volume, and poorer episodic memory performance. Both phenotypes are common in patients with SCZ. Further studies are warranted to investigate whether the present association between SCZ and increased telomere length was driven by such associations, or rather by association with the clinical disease per se or other associated phenotypes, endophenotypes or lifestyle factors.

Keyword(s): Adult (MeSH) ; Age Factors (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Community Health Planning (MeSH) ; Female (MeSH) ; Genetic Predisposition to Disease (MeSH) ; Germany (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Retrospective Studies (MeSH) ; Schizophrenia: genetics (MeSH) ; Telomere: genetics (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. Bonn common (Bonn common)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2013

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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