Journal Article

DZNE-2020-03586

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Staufen2 regulates neuronal target RNAs.

Heraud-Farlow, J. E. ; Sharangdhar, T. ; Li, X. ; Pfeifer, P. ; Tauber, S. ; Orozco, D.DZNE* ; Hörmann, A. ; Thomas, S. ; Bakosova, A. ; Farlow, A. R. ; Edbauer, D.DZNE* ; Lipshitz, H. D. ; Morris, Q. D. ; Bilban, M. ; Doyle, M. (Corresponding author) ; Kiebler, M. A.

2013
Elsevier [New York, NY]

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Please use a persistent id in citations: doi:10.1016/j.celrep.2013.11.039

Abstract: RNA-binding proteins play crucial roles in directing RNA translation to neuronal synapses. Staufen2 (Stau2) has been implicated in both dendritic RNA localization and synaptic plasticity in mammalian neurons. Here, we report the identification of functionally relevant Stau2 target mRNAs in neurons. The majority of Stau2-copurifying mRNAs expressed in the hippocampus are present in neuronal processes, further implicating Stau2 in dendritic mRNA regulation. Stau2 targets are enriched for secondary structures similar to those identified in the 3' UTRs of Drosophila Staufen targets. Next, we show that Stau2 regulates steady-state levels of many neuronal RNAs and that its targets are predominantly downregulated in Stau2-deficient neurons. Detailed analysis confirms that Stau2 stabilizes the expression of one synaptic signaling component, the regulator of G protein signaling 4 (Rgs4) mRNA, via its 3' UTR. This study defines the global impact of Stau2 on mRNAs in neurons, revealing a role in stabilization of the levels of synaptic targets.

Keyword(s): 3' Untranslated Regions (MeSH) ; Animals (MeSH) ; Cells, Cultured (MeSH) ; Hippocampus: cytology (MeSH) ; Hippocampus: metabolism (MeSH) ; Neurons: metabolism (MeSH) ; RGS Proteins: genetics (MeSH) ; RGS Proteins: metabolism (MeSH) ; RNA Processing, Post-Transcriptional (MeSH) ; RNA Stability (MeSH) ; RNA, Messenger: genetics (MeSH) ; RNA, Messenger: metabolism (MeSH) ; RNA-Binding Proteins: genetics (MeSH) ; RNA-Binding Proteins: metabolism (MeSH) ; Rats (MeSH) ; Rats, Sprague-Dawley (MeSH) ; 3' Untranslated Regions ; RGS Proteins ; RNA, Messenger ; RNA-Binding Proteins ; Stau2 protein, rat ; RGS4 protein

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Contributing Institute(s):

1. Cell Biology of Neurodegeneration (AG Edbauer)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2013

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Database coverage:
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