Journal Article

DZNE-2020-04064

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Comparing speech characteristics in spinocerebellar ataxias type 3 and type 6 with Friedreich ataxia.

Brendel, B. ; Synofzik, M.DZNE* ; Ackermann, H. ; Lindig, T. ; Schölderle, T. ; Schöls, L.DZNE* ; Ziegler, W.

2015
Springer73057 Berlin

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Please use a persistent id in citations: doi:10.1007/s00415-014-7511-8

Abstract: Patterns of dysarthria in spinocerebellar ataxias (SCAs) and their discriminative features still remain elusive. Here we aimed to compare dysarthria profiles of patients with (SCA3 and SCA6 vs. Friedreich ataxia (FRDA), focussing on three particularly vulnerable speech parameters (speaking rate, prosodic modulation, and intelligibility) in ataxic dysarthria as well as on a specific oral non-speech variable of ataxic impairment, i.e., the irregularity of oral motor diadochokinesis (DDK). 30 Patients with SCA3, SCA6, and FRDA, matched for group size (n = 10 each), disease severity, and disease duration produced various speech samples and DDK tasks. A discriminant analysis was used to differentiate speech and non-speech parameters between groups. Regularity of DDK was specifically impaired in SCA3, whereas impairments of speech parameters, i.e., rate and modulation were stronger affected in SCA6. Speech parameters are particularly vulnerable in SCA6, while non-speech oral motor features are notably impaired in SCA3.

Keyword(s): Adult (MeSH) ; Aged (MeSH) ; Dysarthria: etiology (MeSH) ; Dysarthria: physiopathology (MeSH) ; Female (MeSH) ; Friedreich Ataxia: complications (MeSH) ; Friedreich Ataxia: physiopathology (MeSH) ; Humans (MeSH) ; Machado-Joseph Disease: complications (MeSH) ; Machado-Joseph Disease: physiopathology (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Severity of Illness Index (MeSH) ; Speech Disorders: etiology (MeSH) ; Speech Disorders: physiopathology (MeSH) ; Spinocerebellar Ataxias: etiology (MeSH) ; Spinocerebellar Ataxias: physiopathology (MeSH)

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Contributing Institute(s):

1. Parkinson Genetics (AG Gasser)
2. Clinical Neurogenetics (AG Schöls)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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