Journal Article

DZNE-2020-04076

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The inflammasomes and autoinflammatory syndromes.

Broderick, L. (Corresponding author) ; De Nardo, D. ; Franklin, B. S. ; Hoffman, H. M. ; Latz, E. (Last author)DZNE*

2015
Annual Reviews Palo Alto, Calif.

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Please use a persistent id in citations: doi:10.1146/annurev-pathol-012414-040431

Abstract: Inflammation, a vital response of the immune system to infection and damage to tissues, can be initiated by various germline-encoded innate immune-signaling receptors. Among these, the inflammasomes are critical for activation of the potent proinflammatory interleukin-1 cytokine family. Additionally, inflammasomes can trigger and maintain inflammatory responses aimed toward excess nutrients and the numerous danger signals that appear in a variety of chronic inflammatory diseases. We discuss our understanding of how inflammasomes assemble to trigger caspase-1 activation and subsequent cytokine release, describe how genetic mutations in inflammasome-related genes lead to autoinflammatory syndromes, and review the contribution of inflammasome activation to various pathologies arising from metabolic dysfunction. Insights into the mechanisms that govern inflammasome activation will help in the development of novel therapeutic strategies, not only for managing genetic diseases associated with overactive inflammasomes, but also for treating common metabolic diseases for which effective therapies are currently lacking.

Keyword(s): Animals (MeSH) ; Autoimmune Diseases: immunology (MeSH) ; Humans (MeSH) ; Inflammasomes: immunology (MeSH) ; Inflammation: immunology (MeSH) ; Syndrome (MeSH) ; Inflammasomes

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Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2015

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Database coverage:
; Allianz-Lizenz / DFG ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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