Journal Article

DZNE-2020-04519

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases.

Reijs, B. L. R. (Corresponding author) ; Teunissen, C. E. ; Goncharenko, N. ; Betsou, F. ; Blennow, K. ; Baldeiras, I. ; Brosseron, F.DZNE* ; Cavedo, E. ; Fladby, T. ; Froelich, L. ; Gabryelewicz, T. ; Gurvit, H. ; Kapaki, E. ; Koson, P. ; Kulic, L. ; Lehmann, S. ; Lewczuk, P. ; Lleó, A. ; Maetzler, W.DZNE* ; de Mendonça, A. ; Miller, A.-M. ; Molinuevo, J. L. ; Mollenhauer, B. ; Parnetti, L. ; Rot, U. ; Schneider, A.DZNE* ; Simonsen, A. H. ; Tagliavini, F. ; Tsolaki, M. ; Verbeek, M. M. ; Verhey, F. R. J. ; Zboch, M. ; Winblad, B. ; Scheltens, P. ; Zetterberg, H. ; Visser, P. J.

2015
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fneur.2015.00216

Abstract: Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank.

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Contributing Institute(s):

1. Neuroinflammation, Biomarker (AG Heneka)
2. Functional Neurogeriatrics (AG Maetzler)
3. Translational Dementia Research Göttingen (AG Schneider Göttingen)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2015

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Database coverage:
; ; ; ; Clarivate Analytics Master Journal List ; DOAJ Seal ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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