Journal Article (Review Article)

DZNE-2020-04834

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Trained immunity: A program of innate immune memory in health and disease.

Netea, M. G. (Corresponding author) ; Joosten, L. A. B. ; Latz, E.DZNE* ; Mills, K. H. G. ; Natoli, G. ; Stunnenberg, H. G. ; O'Neill, L. A. J. ; Xavier, R. J.

2016
Assoc.60841 Washington, DC

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Please use a persistent id in citations: doi:10.1126/science.aaf1098

Abstract: The general view that only adaptive immunity can build immunological memory has recently been challenged. In organisms lacking adaptive immunity, as well as in mammals, the innate immune system can mount resistance to reinfection, a phenomenon termed 'trained immunity' or 'innate immune memory.' Trained immunity is orchestrated by epigenetic reprogramming, broadly defined as sustained changes in gene expression and cell physiology that do not involve permanent genetic changes such as mutations and recombination, which are essential for adaptive immunity. The discovery of trained immunity may open the door for novel vaccine approaches, new therapeutic strategies for the treatment of immune deficiency states, and modulation of exaggerated inflammation in autoinflammatory diseases.

Keyword(s): Animals (MeSH) ; DNA Methylation (MeSH) ; Epigenesis, Genetic (MeSH) ; Histones: metabolism (MeSH) ; Humans (MeSH) ; Immunity, Innate: genetics (MeSH) ; Immunity, Innate: immunology (MeSH) ; Immunologic Memory: genetics (MeSH) ; Immunologic Memory: immunology (MeSH) ; Infections: immunology (MeSH) ; Inflammation: immunology (MeSH) ; Invertebrates: immunology (MeSH) ; Plants: immunology (MeSH) ; Transcription, Genetic (MeSH) ; Vaccination (MeSH) ; Vaccines: immunology (MeSH) ; Histones ; Vaccines

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Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF >= 40 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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