Journal Article

DZNE-2020-05339

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases.

Nimsanor, N. ; Jørring, I. ; Rasmussen, M. A. ; Clausen, C. ; Mau-Holzmann, U. A. ; Bus, C.DZNE* ; Hoffmann, S. A.DZNE* ; Gasser, T.DZNE* ; Kluba, T. ; Holst, B. ; Schmid, B. (Corresponding author)

2016
Elsevier Amsterdam [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.scr.2016.09.019

Abstract: Induced pluripotent stem cells (iPSCs) hold great promise to model diseases, where the disease affected cell type is difficult to access. A major obstacle for the development of disease models is the lack of well characterized control iPSCs from old people not affected by such a disease. Furthermore, gene-editing approaches often require iPSCs from healthy donors, where pathogenic mutations can be inserted if patient material is not available. Here, we report the generation of an iPSC line (16423 #6) from a 77-year-old woman, who did not display any disease symptoms at the time, when the skin biopsy was taken.

Keyword(s): Aged (MeSH) ; Cell Differentiation (MeSH) ; Cell Line (MeSH) ; Cellular Reprogramming (MeSH) ; Ectoderm: cytology (MeSH) ; Ectoderm: metabolism (MeSH) ; Female (MeSH) ; Fibroblasts: cytology (MeSH) ; Healthy Volunteers (MeSH) ; Humans (MeSH) ; Induced Pluripotent Stem Cells: cytology (MeSH) ; Induced Pluripotent Stem Cells: metabolism (MeSH) ; Karyotype (MeSH) ; Microscopy, Fluorescence (MeSH) ; Skin: cytology (MeSH) ; Transcription Factors: genetics (MeSH) ; Transcription Factors: metabolism (MeSH) ; Transcription Factors

---

Contributing Institute(s):

1. Parkinson Genetics (AG Gasser)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2016

---

Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; DOAJ Seal ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---