Journal Article

DZNE-2020-05436

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation.

Bhattacharya, S. ; Herrera-Molina, R. ; Sabanov, V. ; Ahmed, T. ; Iscru, E. ; Stöber, F. ; Richter, K. ; Fischer, K.-D. ; Angenstein, F.DZNE* ; Goldschmidt, J. ; Beesley, P. W. ; Balschun, D. ; Smalla, K.-H. ; Gundelfinger, E. D.DZNE* ; Montag, D. (Corresponding author)

2017
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.biopsych.2016.03.2107

Abstract: Neuroplastin cell recognition molecules have been implicated in synaptic plasticity. Polymorphisms in the regulatory region of the human neuroplastin gene (NPTN) are correlated with cortical thickness and intellectual abilities in adolescents and in individuals with schizophrenia.We characterized behavioral and functional changes in inducible conditional neuroplastin-deficient mice.We demonstrate that neuroplastins are required for associative learning in conditioning paradigms, e.g., two-way active avoidance and fear conditioning. Retrograde amnesia of learned associative memories is elicited by inducible neuron-specific ablation of Nptn gene expression in adult mice, which shows that neuroplastins are indispensable for the availability of previously acquired associative memories. Using single-photon emission computed tomography imaging in awake mice, we identified brain structures activated during memory recall. Constitutive neuroplastin deficiency or Nptn gene ablation in adult mice causes substantial electrophysiologic deficits such as reduced long-term potentiation. In addition, neuroplastin-deficient mice reveal profound physiologic and behavioral deficits, some of which are related to depression and schizophrenia, which illustrate neuroplastin's essential functions.Neuroplastins are essential for learning and memory. Retrograde amnesia after an associative learning task can be induced by ablation of the neuroplastin gene. The inducible neuroplastin-deficient mouse model provides a new and unique means to analyze the molecular and cellular mechanisms underlying retrograde amnesia and memory.

Keyword(s): Amnesia, Retrograde: genetics (MeSH) ; Amnesia, Retrograde: physiopathology (MeSH) ; Animals (MeSH) ; Association Learning: physiology (MeSH) ; Avoidance Learning: physiology (MeSH) ; Behavior, Animal: physiology (MeSH) ; Excitatory Postsynaptic Potentials (MeSH) ; Fear: physiology (MeSH) ; Hippocampus: physiology (MeSH) ; Membrane Glycoproteins: genetics (MeSH) ; Membrane Glycoproteins: physiology (MeSH) ; Memory: physiology (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Mice, Knockout (MeSH) ; Membrane Glycoproteins ; neuroplastin protein, mouse

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Contributing Institute(s):

1. Functional Neuroimaging (AG Angenstein)
2. U Preclinical Researchers T1 - Magdeburg (U Preclinical Researchers T1 - Magdeburg)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2017

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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