Excitatory Microcircuits within Superficial Layers of the Medial Entorhinal Cortex.

Winterer, Jochen; Breustedt, Jörg; Kempter, Richard; D'Albis, Tiziano; Peng, Yangfan; Wozny, Christian; Maier, Nikolaus; Schmitz, Dietmar; Evangelista, Roberta; Beed, Prateep

doi:10.1016/j.celrep.2017.04.041

Journal Article

DZNE-2020-05609

Excitatory Microcircuits within Superficial Layers of the Medial Entorhinal Cortex.

Winterer, J. ; Maier, N. ; Wozny, C. ; Beed, P. ; Breustedt, J. ; Evangelista, R. ; Peng, Y. ; D'Albis, T. ; Kempter, R. ; Schmitz, D. (Last author)DZNE*

2017
Elsevier [New York, NY]

Cell reports 19(6), 1110-1116 (2017) [10.1016/j.celrep.2017.04.041]

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Please use a persistent id in citations: doi:10.1016/j.celrep.2017.04.041

Abstract: The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on the local microcircuitry. However, local networks within the MEC are still not sufficiently characterized. Here, applying up to eight simultaneous whole-cell recordings in acute brain slices, we demonstrate the existence of unitary excitatory connections between principal neurons in the superficial layers of the MEC. In particular, we find prevalent feed-forward excitation from pyramidal neurons in layer III and layer II onto stellate cells in layer II, which might contribute to the generation or the inheritance of grid cell patterns.

Keyword(s): Animals (MeSH) ; Entorhinal Cortex: cytology (MeSH) ; Entorhinal Cortex: physiology (MeSH) ; Excitatory Postsynaptic Potentials (MeSH) ; Female (MeSH) ; Male (MeSH) ; Nerve Net (MeSH) ; Pyramidal Cells: physiology (MeSH) ; Rats (MeSH) ; Rats, Wistar (MeSH)