Progression of Cognitive Decline in Parkinson's Disease.

Roheger, Mandy; Liepelt-Scarfone, Inga; Kalbe, Elke

doi:10.3233/JPD-181306

Journal Article (Review Article)

DZNE-2020-06332

Progression of Cognitive Decline in Parkinson's Disease.

Roheger, M. ; Kalbe, E. ; Liepelt-Scarfone, I. (Last author)DZNE*

2018
IOS Press Amsterdam

Journal of Parkinson's Disease 8(2), 183-193 (2018) [10.3233/JPD-181306]

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Please use a persistent id in citations: doi:10.3233/JPD-181306

Abstract: Cognitive dysfunction is one of the most prevalent non-motor symptoms in Parkinson's disease (PD), often experienced as more debilitating for patients and caregivers than motor problems. Therefore, a deeper understanding of the course of cognitive decline and the identification of valid progression markers for Parkinson's disease dementia (PDD) is essential.Objective: This systematic review summarizes the current state of knowledge on cognitive decline over time by reporting effect sizes of cognitive changes in neuropsychological tests.Methods: 1368 studies were identified by a PubMed database search and 25 studies by additionally scanning previous literature. After screening all records, including 69 full-text article reviews, 12 longitudinal studies on the progression of cognitive decline in PD met our criteria (e.g., sample size ≥50 patients).Results: Only a few studies monitored cognitive decline over a longer period (>4 years). Most studies focused on the evaluation of change in global cognitive state by use of the Mini-Mental State Examination, whereas the use of neuropsychological tests was highly heterogenic among studies. Only one study evaluated patients' cognitive performance in all specified domains (executive function, attention & working memory, memory, language, and visual-spatial function) allowing for diagnosis of cognitive impairment according to consensus guidelines. Medium to strong effect sizes could only be observed in studies with follow-up intervals of four years or longer.Conclusions: The results emphasize the need for the assessment of larger PD cohorts over longer periods of follow-up with a comprehensive neuropsychological battery.

Keyword(s): Attention: physiology (MeSH) ; Cognition: physiology (MeSH) ; Cognition Disorders: complications (MeSH) ; Cognition Disorders: pathology (MeSH) ; Disease Progression (MeSH) ; Executive Function: physiology (MeSH) ; Humans (MeSH) ; Language (MeSH) ; Memory, Short-Term: physiology (MeSH) ; Neuropsychological Tests (MeSH) ; Parkinson Disease: complications (MeSH) ; Parkinson Disease: pathology (MeSH)