Journal Article (Review Article)

DZNE-2020-06486

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Septo-hippocampal interaction.

Müller, C. (First author)DZNE* ; Remy, S. (Last author)DZNE*

2018
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00441-017-2745-2

Abstract: The septo-hippocampal pathway adjusts CA1 network excitability to different behavioral states and is crucially involved in theta rhythmogenesis. In the medial septum, cholinergic, glutamatergic and GABAergic neurons form a highly interconnected local network. Neurons of these three classes project to glutamatergic pyramidal neurons and different subsets of GABAergic neurons in the hippocampal CA1 region. From there, GABAergic neurons project back to the medial septum and form a feedback loop between the two remote brain areas. In vivo, the firing of GABAergic medial septal neurons is theta modulated, while theta modulation is not observed in cholinergic neurons. One prominent feature of glutamatergic neurons is the correlation of their firing rates to the animals running speed. The cellular diversity, the high local interconnectivity and different activity patterns of medial septal neurons during different behaviors complicate the functional dissection of this network. New technical advances help to define specific functions of individual cell classes. In this review, we seek to highlight recent findings and elucidate functional implications of the septo-hippocampal connectivity on the microcircuit scale.

Keyword(s): Animals (MeSH) ; Behavior: physiology (MeSH) ; Cholinergic Neurons: metabolism (MeSH) ; GABAergic Neurons: metabolism (MeSH) ; Hippocampus: anatomy & histology (MeSH) ; Hippocampus: physiology (MeSH) ; Humans (MeSH) ; Locomotion (MeSH) ; Memory (MeSH) ; Models, Neurological (MeSH) ; Pyramidal Cells: metabolism (MeSH) ; Septal Nuclei: anatomy & histology (MeSH) ; Septal Nuclei: physiology (MeSH) ; Theta Rhythm (MeSH)

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Contributing Institute(s):

1. Neuronal Networks (AG Remy)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2018

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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