Journal Article

DZNE-2020-07027

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.

Huang, C. (First author)DZNE* ; Wagner-Valladolid, S. ; Stephens, A. D. ; Jung, R.DZNE* ; Poudel, C. ; Sinnige, T. ; Lechler, M. C.DZNE* ; Schlörit, N.DZNE* ; Lu, M. ; Laine, R. F. ; Michel, C. H. ; Vendruscolo, M. ; Kaminski, C. F. ; Kaminski Schierle, G. S. (Corresponding author) ; David, D. C. (Last author)DZNE*

2019
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: doi:10.7554/eLife.43059

Abstract: Reduced protein homeostasis leading to increased protein instability is a common molecular feature of aging, but it remains unclear whether this is a cause or consequence of the aging process. In neurodegenerative diseases and other amyloidoses, specific proteins self-assemble into amyloid fibrils and accumulate as pathological aggregates in different tissues. More recently, widespread protein aggregation has been described during normal aging. Until now, an extensive characterization of the nature of age-dependent protein aggregation has been lacking. Here, we show that age-dependent aggregates are rapidly formed by newly synthesized proteins and have an amyloid-like structure resembling that of protein aggregates observed in disease. We then demonstrate that age-dependent protein aggregation accelerates the functional decline of different tissues in C. elegans. Together, these findings imply that amyloid-like aggregates contribute to the aging process and therefore could be important targets for strategies designed to maintain physiological functions in the late stages of life.

Keyword(s): Aging (MeSH) ; Amyloid: metabolism (MeSH) ; Animals (MeSH) ; Caenorhabditis elegans: physiology (MeSH) ; Caenorhabditis elegans Proteins: metabolism (MeSH) ; Protein Aggregates (MeSH)

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Contributing Institute(s):

1. Protein Aggregation and Aging (AG David)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2019

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Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; IF >= 5 ; JCR ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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