Journal Article

DZNE-2020-07187

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging.

Albrecht, F. (Corresponding author) ; Mueller, K. ; Ballarini, T. ; Lampe, L. ; Diehl-Schmid, J. ; Fassbender, K. ; Fliessbach, K. ; Jahn, H. ; Jech, R. ; Kassubek, J. ; Kornhuber, J. ; Landwehrmeyer, B. ; Lauer, M. ; Ludolph, A. C. ; Lyros, E. ; Prudlo, J.DZNE* ; Schneider, A. ; Synofzik, M.DZNE* ; Wiltfang, J.DZNE* ; Danek, A. ; Otto, M. ; FTLD-Consortium ; Schroeter, M. L. ; Anderl-Straub, S. ; Brüggen, K. ; Fischer, M. ; Förstl, H. ; Hammer, A. ; Homola, G. ; Just, W. ; Levin, J. ; Marroquin, N. ; Marschhauser, A. ; Nagl, M. ; Oberstein, T. ; Polyakova, M. ; Pellkofer, H. ; Richter-Schmidinger, T. ; Rossmeier, C. ; Schuemberg, K. ; Semler, E. ; Spottke, A. ; Steinacker, P. ; Thöne-Otto, A. ; Uttner, I. ; Zech, H.

2019
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.cortex.2019.02.015

Abstract: Alien limb phenomenon is a rare syndrome associated with a feeling of non-belonging and disowning toward one's limb. In contrast, anarchic limb phenomenon leads to involuntary but goal-directed movements. Alien/anarchic limb phenomena are frequent in corticobasal syndrome (CBS), an atypical parkinsonian syndrome characterized by rigidity, akinesia, dystonia, cortical sensory deficit, and apraxia. The structure-function relationship of alien/anarchic limb was investigated in multi-centric structural magnetic resonance imaging (MRI) data. Whole-group and single-subject comparisons were made in 25 CBS and eight CBS-alien/anarchic limb patients versus controls. Support vector machine was used to see if CBS with and without alien/anarchic limb could be distinguished by structural MRI patterns. Whole-group comparison of CBS versus controls revealed asymmetric frontotemporal atrophy. CBS with alien/anarchic limb syndrome versus controls showed frontoparietal atrophy including the supplementary motor area contralateral to the side of the affected limb. Exploratory analysis identified frontotemporal regions encompassing the pre-/and postcentral gyrus as compromised in CBS with alien limb syndrome. Classification of CBS patients yielded accuracies of 79%. CBS-alien/anarchic limb syndrome was differentiated from CBS patients with an accuracy of 81%. Predictive differences were found in the cingulate gyrus spreading to frontomedian cortex, postcentral gyrus, and temporoparietoocipital regions. We present the first MRI-based group analysis on CBS-alien/anarchic limb. Results pave the way for individual clinical syndrome prediction and allow understanding the underlying neurocognitive architecture.

Keyword(s): Aged (MeSH) ; Alien Limb Phenomenon: diagnostic imaging (MeSH) ; Brain: diagnostic imaging (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Image Processing, Computer-Assisted (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Parkinsonian Disorders: diagnostic imaging (MeSH)

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Contributing Institute(s):

1. Clinical Dementia Research Rostock /Greifswald (AG Teipel)
2. Parkinson Genetics (AG Gasser 1)
3. Alzheimer Biomarker and Clinical Study Group (AG Wiltfang)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 345 - Population Studies and Genetics (POF3-345) (POF3-345)
3. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2019

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; IF < 5 ; JCR ; SCOPUS ; Social Sciences Citation Index ; Web of Science Core Collection

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