Journal Article

DZNE-2020-07257

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Orthostatic hypotension as a risk factor for longitudinal deterioration of cognitive function in the elderly.

Zimmermann, M. (First author)DZNE* ; Wurster, I.DZNE* ; Lerche, S.DZNE* ; Röben, B.DZNE* ; Machetanz, G.DZNE* ; Sünkel, U. ; von Thaler, A.-K. ; Eschweiler, G. W.DZNE* ; Fallgatter, A.DZNE* ; Maetzler, W. ; Berg, D. ; Brockmann, K. (Last author)DZNE*

2020
Blackwell Science78889 Oxford

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Please use a persistent id in citations: doi:10.1111/ene.14050

Abstract: Orthostatic hypotension is frequent with aging with a prevalence of 20%-30% in people aged 65 or older and is considered to increase the risk for coronary events, strokes and dementia. Our objective was to characterize the association of orthostatic hypotension and cognitive function longitudinally over 6 years in a large cohort of the elderly aged over 50 years.In all, 495 participants were assessed longitudinally with the Schellong test and comprehensive cognitive testing using the extended CERAD neuropsychological test battery at baseline and after 6 years. In a subgroup of 92 participants, cerebral magnetic resonance imaging was evaluated for white matter changes using a modified version of the Fazekas score.The prevalence of orthostatic hypotension increases with aging reaching up to 30% in participants aged >70 years. Participants with orthostatic hypotension presented with a higher vascular burden index (1.03 vs. 0.69, P ≤ 0.001), tended to have a higher prevalence of cerebral white matter hyperintensities (91.7% vs. 68.8%, P = 0.091) and showed a faster deterioration in executive and memory function (Trail Making Test B 95 vs. 87 s, P ≤ 0.001; word list learning sum -0.53 vs. 0.38, P = 0.002) compared to participants without orthostatic hypotension.Orthostatic hypotension seems to be associated with cognitive decline longitudinally.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Cognitive Dysfunction: diagnostic imaging (MeSH) ; Cognitive Dysfunction: epidemiology (MeSH) ; Cohort Studies (MeSH) ; Disease Progression (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Hypotension, Orthostatic: complications (MeSH) ; Hypotension, Orthostatic: diagnostic imaging (MeSH) ; Hypotension, Orthostatic: psychology (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Neuropsychological Tests (MeSH) ; Prevalence (MeSH) ; Risk Factors (MeSH) ; Trail Making Test (MeSH) ; White Matter: diagnostic imaging (MeSH)

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Contributing Institute(s):

1. Tübingen common (Tübingen common)
2. Biobanking Facility (Tübingen) (Biobanking Facility (Tübingen))
3. Parkinson Genetics (AG Gasser)
4. Core ICRU (ICRU)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2020

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; IF >= 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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