Journal Article

DZNE-2020-07268

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Increased compensatory kidney workload results in cellular damage in a short time porcine model of mixed acidemia - Is acidemia a 'first hit' in acute kidney injury?

Russ, M. (Corresponding author) ; Ott, S. ; Bedarf, J. R.DZNE* ; Kirschfink, M. ; Hiebl, B. ; Unger, J. K.

2019
PLOS San Francisco, California, US

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Please use a persistent id in citations: doi:10.1371/journal.pone.0218308

Abstract: Acute kidney injury (AKI) corrupts the outcome of about 50% of all critically ill patients. We investigated the possible contribution of the pathology acidemia on the development of AKI. Pigs were exposed to acidemia, acidemia plus hypoxemia or a normal acid-base balance in an experimental setup, which included mechanical ventilation and renal replacement therapy to facilitate biotrauma caused by extracorporeal therapies. Interestingly, extensive histomorphological changes like a tubular loss of cell barriers occurred in the kidneys after just 5 hours exposure to acidemia. The additional exposure to hypoxemia aggravated these findings. These 'early' microscopic pathologies opposed intra vitam data of kidney function. They did not mirror cellular or systemic patterns of proinflammatory molecules (like TNF-α or IL 18) nor were they detectable by new, sensitive markers of AKI like Neutrophil gelatinase-associated lipocalin. Instead, the data suggest that the increased renal proton excretion during acidemia could be an 'early' first hit in the multifactorial pathogenesis of AKI.

Keyword(s): Acid-Base Imbalance: complications (MeSH) ; Acute Kidney Injury: etiology (MeSH) ; Animals (MeSH) ; Hypoxia (MeSH) ; Kidney: physiopathology (MeSH) ; Kidney Tubules: pathology (MeSH) ; Protons (MeSH) ; Swine (MeSH)

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Contributing Institute(s):

1. Prion and prion-like diseases (AG Tamgüney 2)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2019

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Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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